Compound
4-methoxy-17beta-estradiol
A 17β-hydroxy steroid that is 17β-estradiol in which the hydrogen at position 4 has been replaced by a methoxy group.
Definition from ChEBI (CHEBI:136975), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C19H26O3
- Mass
- 302.414 g/mol
- Charge
- 0
- InChIKey
- BCWZIZLVBYHFES-PYEWSWHRSA-N
- SMILES
- [H][C@@]12CCc3c(ccc(O)c3OC)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Chemical structure
- 4-methoxy-17beta-estradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:136975Inferred only
Statements
3 statements
3 statements · 1 reference database · Subject: 4-methoxy-17beta-estradiol · Sources: Rhea
- 4-hydroxy-17beta-estradiol is converted to 4-methoxy-17beta-estradiolCompoundRhea RHEA:53096Inferred only
- 4-methoxy-17beta-estradiol is converted to 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate)CompoundRhea RHEA:53080Inferred only
- 4-methoxy-17beta-estradiol is metabolised by UGT1A8ProteinRhea RHEA:53080Inferred only
Reactions
2 reactions
4-methoxy-17beta-estradiol+UDP-alpha-D-glucuronate4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:53080CC BY 4.0Reference data
4-hydroxy-17beta-estradiol+S-adenosyl-L-methionine4-methoxy-17beta-estradiol+S-adenosyl-L-homocysteine+hydron
Catalysed by COMT
Reaction pageLeft to rightBalanced
Rhea RHEA:53096CC BY 4.0Reference data
Other names
10 names
Resolves to: 4-methoxy-17beta-estradiol
- Also called
- (17beta)-4-methoxyestra-1,3,5(10)-triene-3,17-diol(17β)-4-methoxyestra-1,3,5(10)-triene-3,17-diol4-MeOE24-Methoxy-3,17beta-dihydroxy-1,3,5[10]-estratriene4-methoxy-estra-1,3,5(10)-triene-3,17beta-diol4-Methoxyestradiol4-Methoxyestradiol-17betaST 19:3;O3
- Systematic name
- 4-methoxyestra-1,3,5(10)-triene-3,17beta-diol4-methoxyestra-1,3,5(10)-triene-3,17β-diol