CHEBI:16108

Three steps

• S-butanoyl-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 6 moreperoxisome, cytosol

• S-octanoyl-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, CROT, NUDT19, NUDT7 and 1 moreperoxisome, mitochondrial matrix

• decanoyl-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosol

• S-dodecanoyl-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• tetradecanoyl-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• an acyl-4'-phosphopantetheineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 4 moreperoxisome, Golgi apparatus

• tauroursodeoxycholateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine to tauroursodeoxycholate conversion

  Catalysed by GNPAT, BAATperoxisome, cytosolOne of 2 routes

• glycoursodeoxycholateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine to glycoursodeoxycholate conversion

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1peroxisome, mitochondrial matrix, cytosolOne of 2 routes

• leukotriene F4Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. leukotriene F4 hydrolysis

  Catalysed by GNPAT, ZDHHC11B, NAA10, ESCO2 and 29 moreperoxisome, cytosol

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of leukotriene E4 (cytosol to extracellular)

  Catalysed by GNPAT, ZDHHC11B, NAA10, ESCO2 and 30 moreperoxisome, cytosol, extracellular spaceOne of 2 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix

• N-octadecanoylglycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 2 routes

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 2 routes

• acetoacetateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of acetoacetate and pyruvate (cytosol to mitochondria)

  No catalyst recordedcytosol, mitochondrial matrixOne of 4 routes

• 2-hydroxyoctanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

  Catalysed by GNPAT, CROT, PHYHperoxisome, mitochondrial matrix

• 2-hydroxydecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosol

• 2-hydroxyeicosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 2-hydroxydodecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 2-hydroxytetradecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 11-cis-retinyl tetradecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 2 routes

• 9-cis-retinyl tetradecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 13-cis-retinyl tetradecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• all-trans-retinyl tetradecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• tetradecyl tetradecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• beta-D-fructose 1-phosphateReach from here →
  1. Alkaline Phosphatase
  2. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)
  3. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate

  Catalysed by ALPL, ALPP, ALPI, ALPG and 2 morecytosol

• N-hexadecanoylglycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix

• N-dodecanoylglycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 2 routes

• N-decanoylglycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosolOne of 2 routes

• N-octanoylglycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by GNPAT, CROT, GLYATL2peroxisome, mitochondrial matrixOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 2 moreperoxisome, mitochondrial matrix

• an N-octadecanoyl-sphingoid baseReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• glycyldehydrophenylalanineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix

• an N-(fatty acyl)-glycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1peroxisome, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1B and 1 moreperoxisome, cytosol

• acetaldehydeReach from here →
  1. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
  2. deoxyribose-phosphate aldolase
  3. deoxyribose-phosphate aldolase

  Catalysed by TPI1, DERAcytosol

• acetylcholineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by GNPAT, CHATperoxisome, nucleus, cytosolOne of 3 routes

• acetylpyruvateReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by FAHD1cytosol

• all-trans-retinoic acidReach from here →
  1. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15467Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by GNPAT, AACS, HMGCS1peroxisome, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 2 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• (S)-malateReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by GNPAT, ACLYperoxisome, cytosol, mitochondrial matrixOne of 7 routes

• L-leucineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 21 routes

• CHEBI:15611Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, cytosol

• CHEBI:15699Reach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 17 routes

• betaine aldehydeReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by GNPAT, CHAT, CHDHperoxisome, nucleus, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. glyceronephosphate O-acyltransferase (DHAP)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by GNPAT, SAT1, SAT2, DHPSperoxisome, cytosolOne of 2 routes