CHEBI:15727

Three steps

• N-(9Z-octadecenoyl)glycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by CNDP1, CNDP2, SLC7A6, PM20D1cytosol, extracellular space

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by CNDP1, CNDP2, SLC7A6, PM20D1cytosol, extracellular space

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by CNDP1, CNDP2, SLC7A6, PM20D1cytosol, extracellular space

• N-octadecanoylglycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 2 routes

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• 2-hydroxyoctanoyl-CoAReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

  Catalysed by NAA10, CROT, PHYHcytosol, mitochondrial matrix

• 2-hydroxydecanoyl-CoAReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

  Catalysed by NAA10, ACSM4, ACSM1, ACSM2A and 4 morecytosol

• 2-hydroxyeicosanoyl-CoAReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 2-hydroxydodecanoyl-CoAReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 2-hydroxytetradecanoyl-CoAReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 11-cis-retinyl tetradecanoateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• 9-cis-retinyl tetradecanoateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 13-cis-retinyl tetradecanoateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• all-trans-retinyl tetradecanoateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• tetradecyl tetradecanoateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• N-hexadecanoylglycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• N-dodecanoylglycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• N-decanoylglycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by NAA10, ACSM4, ACSM1, ACSM2A and 4 morecytosolOne of 2 routes

• N-octanoylglycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by NAA10, CROT, GLYATL2cytosol, mitochondrial matrixOne of 2 routes

• D-histidineReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by CNDP1, CNDP2, GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)

  Catalysed by CNDP1, CNDP2, GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix

• an N-octadecanoyl-sphingoid baseReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• glycyldehydrophenylalanineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by CNDP1, CNDP2, SLC7A6, PFAScytosol, extracellular space

• kinetensinReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by CNDP1, CNDP2, SLC7A6, CMA1cytosol, extracellular spaceOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by NAA10, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by NAA10, CPT1A, CPT1C, CPT1B and 1 morecytosol

• acetaldehydeReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by CNDP1, CNDP2, SLC7A6cytosol, extracellular space

• acetylcholineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by NAA10, CHATcytosol, nucleusOne of 3 routes

• pyruvateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by NAA10, AGXT2cytosol, mitochondrial matrixOne of 20 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by CNDP1, CNDP2, SLC7A6, TPH1 and 1 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:15467Reach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by NAA10, AACS, HMGCS1cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (S)-malateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by NAA10, ACLYcytosol, mitochondrial matrixOne of 5 routes

• CHEBI:15611Reach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by NAA10, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by CNDP1, CNDP2, SLC7A6, TPH1 and 1 morecytosol, extracellular spaceOne of 2 routes

• betaine aldehydeReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by NAA10, CHAT, CHDHcytosol, nucleusOne of 3 routes

• trimethylenediamineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by NAA10, SAT1, SAT2, DHPScytosolOne of 3 routes

• hexadecanoic acidReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by NAA10, CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 4 routes

• CHEBI:15765Reach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of histidine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by CNDP1, CNDP2, SLC7A6, THcytosol, extracellular spaceOne of 5 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by NAA10, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus

• N-carbamoyl-L-aspartic acidReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by CNDP1, CNDP2, GADL1, CSAD and 1 morecytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Nalpha-(beta-alanyl)-L-histidine hydrolase
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by CNDP1, CNDP2, SLC7A6, GFPT2 and 1 morecytosol, extracellular space

• phosphatidylethanolamineReach from here →
  1. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by NAA10, ASAH1, ACER2, ACER1 and 6 morecytosol, Golgi apparatus