2,4-dinitrophenyl-S-glutathione

Three steps

• L-cysteineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. cystine to cysteine conversion

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 9 routes

• diiodineReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2 and 1 moreextracellular space, cytosolOne of 2 routes

• 3,4-dihydroxyphenylacetateReach from here →
  1. transport of dopamine (cytosol to extracellular)
  2. monoamine oxidase (dopamine)
  3. 3,4-dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, AOC2, AOC1 and 6 moreextracellular space, cytosolOne of 3 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. 3,3',5'-triiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 4 moreextracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. Steryl-Sulfatase

  Catalysed by SLCO1A2, SLCO1B3, STSextracellular space, cytosol, Golgi apparatusOne of 7 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLCO1A2, SLCO1B3, AANAT, HADHA and 2 moreextracellular space, cytosol, mitochondrial matrix

• glycerolReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. fatty acid amide hydrolase (2-arachidonoylglycerol)
  3. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by SLCO1B1, FAAH, CES2, ABHD16A and 8 moreextracellular space, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by SLCO1B3, BCHE, ACHE, CES2 and 2 moreextracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2
  3. L-histidine = trans-urocanate + NH4(+)

  Catalysed by SLCO1A2, SLCO1B3, HDC, HALextracellular space, cytosol

• urateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, SLC22A13extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• methylarsonous acidReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GSTO1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:17895Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• fumaric acidReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:18019Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A6extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5extracellular space, cytosolOne of 4 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. Utilized Transport
  3. solute carrier (L-carnitine)

  Catalysed by SLCO1B1, SLC25A20extracellular space, cytosol, endoplasmic reticulum, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. ATP:choline phosphotransferase

  Catalysed by SLCO1B3, BCHE, ACHE, CHKA and 1 moreextracellular space, cytosol

• dodecanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLCO1B1, GARTextracellular space, cytosol

• arsenic triglutathioneReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, AS3MTextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• (R)-metanephrineReach from here →
  1. transport of noradrenaline (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:catechol O-methyltransferase
  3. (R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLCO1A2, SLCO1B3, COMT, LRTOMT and 1 moreextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLCO1B1, GSSextracellular space, cytosol

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, MGST3extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GPX1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GPX1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GPX1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GPX1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GPX4extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• deoxycholate 3-sulfateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cytochrome P450 (cholate)
  3. deoxycholate + 3'-phosphoadenylyl sulfate = deoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, CYP7A1, SULT2A1extracellular space, cytosol

• 3',5'-diiodo-L-thyronineReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3extracellular space, cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLCO1B1, AGXT2extracellular space, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLCO1B1, SHMT1extracellular space, cytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, HADHA and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (S)-lactoyl-AMPReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, AARS1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (S)-lactoyl-CoAReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, ACSS2extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosol

• (7Z)-tetradecenoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosol

• (R)-adrenaline 4'-O-sulfateReach from here →
  1. transport of noradrenaline (cytosol to extracellular)
  2. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)
  3. (R)-adrenaline + 3'-phosphoadenylyl sulfate = (R)-adrenaline 4'-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, PNMT, SULT1A3 and 1 moreextracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLCO1A2, SLCO1B3, AANAT, HADHA and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (2E,5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O2

  Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 9 moreextracellular space, cytosol

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLCO1A2, SLCO1B3, AANAT, HADHA and 2 moreextracellular space, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ECHS1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ECHS1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GSTP1extracellular space, cytosol, inner side of the membrane, outer side of the membrane