leukotriene F4

Three steps

• spermidineReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 14 routes

• L-tryptophanReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 9 routes

• L-alanineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. glutathione gamma-glutamylaminopeptidase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 moreextracellular space, cytosolOne of 23 routes

• L-asparagineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 9 routes

• L-phenylalanineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 13 routes

• L,L-cystathionineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. L-serine hydro-lyase (adding homocysteine

  Catalysed by CBSextracellular space, cytosolOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by GCLC, GCLMextracellular space, cytosolOne of 2 routes

• L-tyrosineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by AADATcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT2cytosol

• an acyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, Golgi apparatusOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by CARS2extracellular space, cytosol

• N(tau)-methylhistamineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, HNMTextracellular space, cytosolOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 4 routes

• hyodeoxycholateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by SLCO1B1, FAAH, PM20D1extracellular space, cytosolOne of 3 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by PPCSextracellular space, cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 9 routes

• N-benzoylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. Hippurate (Benzoylglycinate) Formation

  No catalyst recordedcytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by CDO1extracellular space, cytosolOne of 2 routes

• decanoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• chenodeoxycholoyl-CoAReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + ATP + CoA = chenodeoxycholoyl-CoA + AMP + diphosphate

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosol

• CHEBI:63544Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. cytochrome P450 (arachidonate)

  Catalysed by SLCO1B1, CYP4F8extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• ubiquinol-10Reach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosol

• hexacosanoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 9 routes

• (R)-adrenalineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 8 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 4 routes

• CHEBI:742324Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes