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Proteins/UNIPROT:Q9UQ88
Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing. Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly. Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors. Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation. Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD..
[Isoform SV6]: Isoform expressed in a non-cell cycle-dependent manner..
[Isoform 4]: Isoform specifically expressed during the G2-M phases of the cell cycle. Phosphorylates 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. Promotes centromeric transcription to maintain centromeric cohesion during mitosis..
Function from UniProtKB (Q9UQ88), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
54 statements
54 statements · 5 reference databases · Subject: CDK11A · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
3 reactions
7 names
Resolves to: CDK11A
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17989CC BY 4.0Reference data