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Proteins/UNIPROT:O75063
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized..
Function from UniProtKB (O75063), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
87 statements
87 statements · 5 reference databases · Subject: FAM20B · Sources: gene ontology, Hetionet, Human-GEM, Reactome, UniProt
3 reactions
ATP+D-glucitolADP+proton+MAM02917c
Catalysed by FAM20B
Reaction pageLeft to rightBalancedEC 2.7.1.-cytosol
Human-GEM MAR04317CC BY 4.0Reference data
ATP+MAM02454cADP+MAM01717c+proton
Catalysed by FAM20B
Reaction pageLeft to rightBalancedEC 2.7.1.-cytosol
2 names
Resolves to: FAM20B
3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein]+ATP(4-)3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by FAM20B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19461CC BY 4.0Reference data