Proteins/UNIPROT:O43182

ARHGAP6

ProteinUNIPROT:O43182

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology..

Function from UniProtKB (O43182), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 3 reference databases · Subject: ARHGAP6 · Sources: gene ontology, Hetionet, Reactome

Order

ARHGAP6 interacts with LNX1ProteinHetionet hetionet:interacts:395-84708Inferred only
ARHGAP6 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
ARHGAP6 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGAP6 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGAP6 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGAP6 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGAP6 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGAP6 regulates negative regulation of focal adhesion assemblyBiological processgene ontology O43182|GO:0051895Inferred only
ARHGAP6 regulates negative regulation of stress fiber assemblyBiological processgene ontology O43182|GO:0051497Inferred only
ARHGAP6 regulates positive regulation of intracellular signal transductionBiological processgene ontology O43182|GO:1902533Inferred only
ARHGAP6 regulates positive regulation of phospholipase C/protein kinase C signal transductionBiological processgene ontology O43182|GO:0141214Inferred only
ARHGAP6 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology O43182|GO:0051056Inferred only

Show the remaining 5

AMIGO3 increases the expression of ARHGAP6ProteinHetionet hetionet:regulates:386724-395Inferred only
GUK1 decreases the expression of ARHGAP6ProteinHetionet hetionet:regulates:2987-395Inferred only
HDAC6 increases the expression of ARHGAP6ProteinHetionet hetionet:regulates:10013-395Inferred only
MAP4K4 increases the expression of ARHGAP6ProteinHetionet hetionet:regulates:9448-395Inferred only
TUBB3 increases the expression of ARHGAP6ProteinHetionet hetionet:regulates:10381-395Inferred only

Other names

3 names

Resolves to: ARHGAP6

Also called: Rho-type GTPase-activating protein 6Rho-type GTPase-activating protein RhoGAPX-1RHOGAP6

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