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Proteins/UNIPROT:Q8N1W1

ARHGEF28

Protein·UNIPROT:Q8N1W1

Open in the graph

Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity)..

Function from UniProtKB (Q8N1W1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

amyotrophic lateral sclerosis has a germline basis in ARHGEF28DiseaseGenCC HGNC:30322|MONDO:0004976Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: ARHGEF28 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ARHGEF28 covaries with CCDC141ProteinHetionet hetionet:covaries:285025-64283Inferred only
ARHGEF28 covaries with CMYA5ProteinHetionet hetionet:covaries:202333-64283Inferred only
ARHGEF28 covaries with FRZBProteinHetionet hetionet:covaries:2487-64283Inferred only
GJA9 covaries with ARHGEF28ProteinHetionet hetionet:covaries:64283-81025Inferred only
ARHGEF28 covaries with GZF1ProteinHetionet hetionet:covaries:64283-64412Inferred only
ARHGEF28 covaries with LENG1ProteinHetionet hetionet:covaries:64283-79165Inferred only
ARHGEF28 covaries with PCDHB10ProteinHetionet hetionet:covaries:56126-64283Inferred only
PRR23A covaries with ARHGEF28ProteinHetionet hetionet:covaries:64283-729627Inferred only
ARHGEF28 covaries with SLC16A14ProteinHetionet hetionet:covaries:151473-64283Inferred only
ARHGEF28 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
ARHGEF28 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ARHGEF28 participates in EPH-Ephrin signalingPathwayReactome R-HSA-2682334Inferred only

Show the remaining 12

ARHGEF28 participates in EPHB-mediated forward signalingPathwayReactome R-HSA-3928662Inferred only
ARHGEF28 participates in Gastrin signalingPathwayWikiPathways WP4659Inferred only
ARHGEF28 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
ARHGEF28 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGEF28 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGEF28 participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
ARHGEF28 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
ARHGEF28 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGEF28 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGEF28 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGEF28 regulates regulation of Rho protein signal transductionBiological processgene ontology Q8N1W1|GO:0035023Inferred only
ARHGEF28 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q8N1W1|GO:0051056Inferred only

Other names

6 names

Resolves to: ARHGEF28

Also called: 190 kDa guanine nucleotide exchange factorKIAA1998p190-RhoGEFp190RhoGEFRGNEFRho guanine nucleotide exchange factor

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