Proteins/UNIPROT:Q8IVF7

FMNL3

ProteinUNIPROT:Q8IVF7

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignment..

Function from UniProtKB (Q8IVF7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 4 reference databases · Subject: FMNL3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

BLOC1S3 covaries with FMNL3ProteinHetionet hetionet:covaries:388552-91010Inferred only
FZD9 covaries with FMNL3ProteinHetionet hetionet:covaries:8326-91010Inferred only
RASGRP2 covaries with FMNL3ProteinHetionet hetionet:covaries:10235-91010Inferred only
FMNL3 covaries with SPON1ProteinHetionet hetionet:covaries:10418-91010Inferred only
APP interacts with FMNL3ProteinHetionet hetionet:interacts:351-91010Inferred only
MMS19 interacts with FMNL3ProteinHetionet hetionet:interacts:64210-91010Inferred only
PRPF40A interacts with FMNL3ProteinHetionet hetionet:interacts:55660-91010Inferred only
UBC interacts with FMNL3ProteinHetionet hetionet:interacts:7316-91010Inferred only
FMNL3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
FMNL3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
FMNL3 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
FMNL3 participates in RHO GTPases Activate ForminsPathwayReactome R-HSA-5663220Inferred only

Show the remaining 8

FMNL3 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
FMNL3 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
FMNL3 participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only
FMNL3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FMNL3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FMNL3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FMNL3 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
FMNL3 regulates regulation of cell shapeBiological processgene ontology Q8IVF7|GO:0008360Inferred only

Other names

7 names

Resolves to: FMNL3

Also called: FHOD3Formin homology 2 domain-containing protein 3FRL2KIAA2014WBP-3WBP3WW domain-binding protein 3

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