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Proteins/UNIPROT:Q9NSV4

DIAPH3

Protein·UNIPROT:Q9NSV4

Open in the graph

Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity..

Function from UniProtKB (Q9NSV4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

autosomal dominant nonsyndromic hearing loss has a germline basis in DIAPH3DiseaseGenCC HGNC:15480|MONDO:0019587Inferred only

Statements

29 statements

29 statements · 3 reference databases · Subject: DIAPH3 · Sources: Hetionet, Reactome, WikiPathways

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CDC42 interacts with DIAPH3ProteinHetionet hetionet:interacts:81624-998Inferred only
CENPA interacts with DIAPH3ProteinHetionet hetionet:interacts:1058-81624Inferred only
HDAC6 interacts with DIAPH3ProteinHetionet hetionet:interacts:10013-81624Inferred only
RAC1 interacts with DIAPH3ProteinHetionet hetionet:interacts:5879-81624Inferred only
RHOA interacts with DIAPH3ProteinHetionet hetionet:interacts:387-81624Inferred only
SMAD9 interacts with DIAPH3ProteinHetionet hetionet:interacts:4093-81624Inferred only
SUMO2 interacts with DIAPH3ProteinHetionet hetionet:interacts:6613-81624Inferred only
UBC interacts with DIAPH3ProteinHetionet hetionet:interacts:7316-81624Inferred only
UBD interacts with DIAPH3ProteinHetionet hetionet:interacts:10537-81624Inferred only
VCP interacts with DIAPH3ProteinHetionet hetionet:interacts:7415-81624Inferred only
DIAPH3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
DIAPH3 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only

Show the remaining 17

DIAPH3 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
DIAPH3 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
DIAPH3 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
DIAPH3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DIAPH3 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
DIAPH3 participates in RHO GTPases Activate ForminsPathwayReactome R-HSA-5663220Inferred only
DIAPH3 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
DIAPH3 participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
DIAPH3 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
DIAPH3 participates in RHOD GTPase cyclePathwayReactome R-HSA-9013405Inferred only
DIAPH3 participates in RHOF GTPase cyclePathwayReactome R-HSA-9035034Inferred only
DIAPH3 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
DIAPH3 participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only
DIAPH3 participates in RHOQ GTPase cyclePathwayReactome R-HSA-9013406Inferred only
DIAPH3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DIAPH3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
DIAPH3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only

Other names

4 names

Resolves to: DIAPH3

Also called: DIAP3Diaphanous-related formin-3DRF3MDia2

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