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Proteins/UNIPROT:Q92608

DOCK2

Protein·UNIPROT:Q92608

Open in the graph

Guanine nucleotide exchange factor (GEF) that activates monomeric GTPases by catalysing the release of bound GDP in exchange for free GTP. Activates RAC1 and RAC2, but not CDC42. Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. May also participate in IL2 transcriptional activation via the activation of RAC2..

Function from UniProtKB (Q92608), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

DOCK2 deficiency has a germline basis in DOCK2DiseaseGenCC HGNC:2988|MONDO:0014637Inferred only

Statements

32 statements

32 statements · 4 reference databases · Subject: DOCK2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CD247 interacts with DOCK2ProteinHetionet hetionet:interacts:1794-919Inferred only
CRKL interacts with DOCK2ProteinHetionet hetionet:interacts:1399-1794Inferred only
DOCK2 interacts with ELMO1ProteinHetionet hetionet:interacts:1794-9844Inferred only
DOCK2 interacts with KHDRBS1ProteinHetionet hetionet:interacts:10657-1794Inferred only
DOCK2 interacts with PAK2ProteinHetionet hetionet:interacts:1794-5062Inferred only
DOCK2 interacts with RAC1ProteinHetionet hetionet:interacts:1794-5879Inferred only
DOCK2 interacts with RAC2ProteinHetionet hetionet:interacts:1794-5880Inferred only
DOCK2 interacts with UBCProteinHetionet hetionet:interacts:1794-7316Inferred only
DOCK2 interacts with VAV1ProteinHetionet hetionet:interacts:1794-7409Inferred only
DOCK2 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
DOCK2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
DOCK2 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only

Show the remaining 20

DOCK2 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
DOCK2 participates in HIV InfectionPathwayReactome R-HSA-162906Inferred only
DOCK2 participates in Host Interactions of HIV factorsPathwayReactome R-HSA-162909Inferred only
DOCK2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
DOCK2 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
DOCK2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
DOCK2 participates in Nef and signal transductionPathwayReactome R-HSA-164944Inferred only
DOCK2 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
DOCK2 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
DOCK2 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
DOCK2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DOCK2 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
DOCK2 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
DOCK2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DOCK2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
DOCK2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
DOCK2 participates in The role of Nef in HIV-1 replication and disease pathogenesisPathwayReactome R-HSA-164952Inferred only
DOCK2 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
DOCK2 regulates positive regulation of phagocytosisBiological processgene ontology Q92608|GO:0050766Inferred only
DOCK2 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q92608|GO:0051056Inferred only

Other names

2 names

Resolves to: DOCK2

Also called: Dedicator of cytokinesis protein 2KIAA0209

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