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Proteins/UNIPROT:O94989
Guanine nucleotide exchange factor (GEF) that activates RhoA, playing a role in the regulation of actin cytoskeleton organization. Is involved in the regulation of vascular smooth muscle contractility. Additionally, it negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2 (By similarity). Does not activate RAC1 or CDC42..
Function from UniProtKB (O94989), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
52 statements
52 statements · 4 reference databases · Subject: ARHGEF15 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
4 names
Resolves to: ARHGEF15