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Proteins/UNIPROT:Q8TCU6

PREX1

Protein·UNIPROT:Q8TCU6

Open in the graph

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Function from UniProtKB (Q8TCU6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

31 statements

31 statements · 4 reference databases · Subject: PREX1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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PREX1 covaries with COPRSProteinHetionet hetionet:covaries:55352-57580Inferred only
MTOR interacts with PREX1ProteinHetionet hetionet:interacts:2475-57580Inferred only
PPP1CA interacts with PREX1ProteinHetionet hetionet:interacts:5499-57580Inferred only
UBC interacts with PREX1ProteinHetionet hetionet:interacts:57580-7316Inferred only
PREX1 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
PREX1 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
PREX1 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
PREX1 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
PREX1 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
PREX1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
PREX1 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
PREX1 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only

Show the remaining 19

PREX1 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
PREX1 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
PREX1 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
PREX1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
PREX1 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
PREX1 participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
PREX1 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
PREX1 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
PREX1 participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only
PREX1 participates in RHOQ GTPase cyclePathwayReactome R-HSA-9013406Inferred only
PREX1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PREX1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
PREX1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
PREX1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
PREX1 regulates negative regulation of TOR signalingBiological processgene ontology Q8TCU6|GO:0032007Inferred only
PREX1 regulates positive regulation of cell migrationBiological processgene ontology Q8TCU6|GO:0030335Inferred only
PREX1 regulates regulation of actin filament polymerizationBiological processgene ontology Q8TCU6|GO:0030833Inferred only
PREX1 regulates regulation of dendrite developmentBiological processgene ontology Q8TCU6|GO:0050773Inferred only
PREX1 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q8TCU6|GO:0051056Inferred only

Other names

3 names

Resolves to: PREX1

Also called: KIAA1415P-Rex1PtdIns(3,4,5)-dependent Rac exchanger 1

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