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Proteins/UNIPROT:O60229

KALRN

Protein·UNIPROT:O60229

Open in the graph

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity..

Function from UniProtKB (O60229), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

41 statements

41 statements · 5 reference databases · Subject: KALRN · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Search this listOrder

ATXN7 interacts with KALRNProteinHetionet hetionet:interacts:6314-8997Inferred only
CACNA1A interacts with KALRNProteinHetionet hetionet:interacts:773-8997Inferred only
CDC5L interacts with KALRNProteinHetionet hetionet:interacts:8997-988Inferred only
COIL interacts with KALRNProteinHetionet hetionet:interacts:8161-8997Inferred only
KALRN interacts with DISC1ProteinHetionet hetionet:interacts:27185-8997Inferred only
KALRN interacts with DTNBP1ProteinHetionet hetionet:interacts:84062-8997Inferred only
EPHB2 interacts with KALRNProteinHetionet hetionet:interacts:2048-8997Inferred only
FASLG interacts with KALRNProteinHetionet hetionet:interacts:356-8997Inferred only
GFI1B interacts with KALRNProteinHetionet hetionet:interacts:8328-8997Inferred only
GNB1 interacts with KALRNProteinHetionet hetionet:interacts:2782-8997Inferred only
KALRN interacts with LNX1ProteinHetionet hetionet:interacts:84708-8997Inferred only
PAM interacts with KALRNProteinHetionet hetionet:interacts:5066-8997Inferred only

Show the remaining 29

KALRN interacts with PRKD2ProteinHetionet hetionet:interacts:25865-8997Inferred only
RAC1 interacts with KALRNProteinHetionet hetionet:interacts:5879-8997Inferred only
SUMO2 interacts with KALRNProteinHetionet hetionet:interacts:6613-8997Inferred only
SUMO3 interacts with KALRNProteinHetionet hetionet:interacts:6612-8997Inferred only
KALRN participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
KALRN participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
KALRN participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
KALRN participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KALRN participates in EPH-Ephrin signalingPathwayReactome R-HSA-2682334Inferred only
KALRN participates in EPHB-mediated forward signalingPathwayReactome R-HSA-3928662Inferred only
KALRN participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
KALRN participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
KALRN participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
KALRN participates in HDAC6 interactions in the central nervous systemPathwayWikiPathways WP5426Inferred only
KALRN participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
KALRN participates in MAPK6/MAPK4 signalingPathwayReactome R-HSA-5687128Inferred only
KALRN participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
KALRN participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
KALRN participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
KALRN participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
KALRN participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
KALRN participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
KALRN participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
KALRN participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KALRN participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
KALRN participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
KALRN participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
KALRN regulates regulation of small GTPase mediated signal transductionBiological processgene ontology O60229|GO:0051056Inferred only
KALRN requires the cofactor magnesium(2+)CompoundUniProt O60229Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

8 names

Resolves to: KALRN

Also called: DUETDUOHAPIPHuntingtin-associated protein-interacting proteinProtein DuoSerine/threonine-protein kinase with Dbl- and pleckstrin homology domainTRADwith Dbl- and pleckstrin homology domain

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Balance undeterminable

Rhea RHEA:17989CC BY 4.0Reference data

L-threonyl-[protein]+ATP(4-)O-phospho-L-threonyl-[protein]+ADP(3-)+hydron

Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or IKBKB or CASK or AURKA or GAK and 341 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:46608CC BY 4.0Reference data