Proteins/UNIPROT:Q9NR80

ARHGEF4

ProteinUNIPROT:Q9NR80

Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression..

Function from UniProtKB (Q9NR80), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

36 statements

36 statements · 4 reference databases · Subject: ARHGEF4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ARHGEF4 covaries with ADAMTS13ProteinHetionet hetionet:covaries:11093-50649Inferred only
ARHGEF4 covaries with EEF2KMTProteinHetionet hetionet:covaries:196483-50649Inferred only
ARHGEF4 covaries with JMJD8ProteinHetionet hetionet:covaries:339123-50649Inferred only
ARHGEF4 covaries with OPTNProteinHetionet hetionet:covaries:10133-50649Inferred only
PPP1R3A covaries with ARHGEF4ProteinHetionet hetionet:covaries:50649-5506Inferred only
ARHGEF4 covaries with WFIKKN1ProteinHetionet hetionet:covaries:117166-50649Inferred only
ARHGEF4 covaries with ZCCHC14ProteinHetionet hetionet:covaries:23174-50649Inferred only
ARHGEF4 covaries with ZFR2ProteinHetionet hetionet:covaries:23217-50649Inferred only
APC interacts with ARHGEF4ProteinHetionet hetionet:interacts:324-50649Inferred only
HLA-B interacts with ARHGEF4ProteinHetionet hetionet:interacts:3106-50649Inferred only
KHDRBS1 interacts with ARHGEF4ProteinHetionet hetionet:interacts:10657-50649Inferred only
RAC1 interacts with ARHGEF4ProteinHetionet hetionet:interacts:50649-5879Inferred only

Show the remaining 24

RHOA interacts with ARHGEF4ProteinHetionet hetionet:interacts:387-50649Inferred only
ARHGEF4 participates in 2q21 1 copy number variation syndromePathwayWikiPathways WP5223Inferred only
ARHGEF4 participates in Activation of STAT3 by cadherin engagementPathwayReactome R-HSA-9958825Inferred only
ARHGEF4 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
ARHGEF4 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARHGEF4 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
ARHGEF4 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
ARHGEF4 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
ARHGEF4 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
ARHGEF4 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
ARHGEF4 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
ARHGEF4 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ARHGEF4 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
ARHGEF4 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
ARHGEF4 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARHGEF4 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
ARHGEF4 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGEF4 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGEF4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGEF4 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ARHGEF4 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGEF4 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGEF4 participates in SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)PathwayReactome R-HSA-9958810Inferred only
ARHGEF4 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q9NR80|GO:0051056Inferred only

Other names

4 names

Resolves to: ARHGEF4

Also called: APC-stimulated guanine nucleotide exchange factor 1AsefAsef1KIAA1112

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