Proteins/UNIPROT:O15013

ARHGEF10

ProteinUNIPROT:O15013

Open in the graph

May play a role in developmental myelination of peripheral nerves..

Function from UniProtKB (O15013), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

autosomal dominant slowed nerve conduction velocity has a germline basis in ARHGEF10DiseaseGenCC HGNC:14103|MONDO:0011998Inferred only

Statements

29 statements

29 statements · 3 reference databases · Subject: ARHGEF10 · Sources: gene ontology, Hetionet, Reactome

Order

ARHGEF10 covaries with COBLProteinHetionet hetionet:covaries:23242-9639Inferred only
ARHGEF10 covaries with DLGAP2ProteinHetionet hetionet:covaries:9228-9639Inferred only
ARHGEF10 covaries with SCN1BProteinHetionet hetionet:covaries:6324-9639Inferred only
ARHGEF10 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARHGEF10 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
ARHGEF10 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
ARHGEF10 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
ARHGEF10 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ARHGEF10 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
ARHGEF10 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
ARHGEF10 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARHGEF10 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only

Show the remaining 17

ARHGEF10 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGEF10 participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
ARHGEF10 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
ARHGEF10 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGEF10 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ARHGEF10 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGEF10 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGEF10 regulates positive regulation of Rho protein signal transductionBiological processgene ontology O15013|GO:0035025Inferred only
ARHGEF10 regulates positive regulation of stress fiber assemblyBiological processgene ontology O15013|GO:0051496Inferred only
ARHGEF10 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology O15013|GO:0051056Inferred only
CDK2 increases the expression of ARHGEF10ProteinHetionet hetionet:regulates:1017-9639Inferred only
FOS decreases the expression of ARHGEF10ProteinHetionet hetionet:regulates:2353-9639Inferred only
LIPT1 increases the expression of ARHGEF10ProteinHetionet hetionet:regulates:51601-9639Inferred only
NRP1 increases the expression of ARHGEF10ProteinHetionet hetionet:regulates:8829-9639Inferred only
PIK3CA increases the expression of ARHGEF10ProteinHetionet hetionet:regulates:5290-9639Inferred only
QRSL1 decreases the expression of ARHGEF10ProteinHetionet hetionet:regulates:55278-9639Inferred only
TBC1D15 decreases the expression of ARHGEF10ProteinHetionet hetionet:regulates:64786-9639Inferred only

Other names

2 names

Resolves to: ARHGEF10

Also called: KIAA0294Rho guanine nucleotide exchange factor 10

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