Proteins/UNIPROT:P43121

MCAM

ProteinUNIPROT:P43121

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration..

Function from UniProtKB (P43121), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

25 statements

25 statements · 4 reference databases · Subject: MCAM · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CENPE covaries with MCAMProteinHetionet hetionet:covaries:1062-4162Inferred only
MTERF1 covaries with MCAMProteinHetionet hetionet:covaries:4162-7978Inferred only
ZNF180 covaries with MCAMProteinHetionet hetionet:covaries:4162-7733Inferred only
MCAM covaries with ZNF691ProteinHetionet hetionet:covaries:4162-51058Inferred only
MCAM interacts with ATF7IPProteinHetionet hetionet:interacts:4162-55729Inferred only
FYN interacts with MCAMProteinHetionet hetionet:interacts:2534-4162Inferred only
PTK2B interacts with MCAMProteinHetionet hetionet:interacts:2185-4162Inferred only
MCAM interacts with SELEProteinHetionet hetionet:interacts:4162-6401Inferred only
MCAM interacts with UBCProteinHetionet hetionet:interacts:4162-7316Inferred only
MCAM interacts with UBE2OProteinHetionet hetionet:interacts:4162-63893Inferred only
MCAM participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
MCAM participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only

Show the remaining 13

MCAM participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
MCAM participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
MCAM participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
MCAM participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
MCAM participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
MCAM participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
MCAM participates in RHOD GTPase cyclePathwayReactome R-HSA-9013405Inferred only
MCAM participates in RHOF GTPase cyclePathwayReactome R-HSA-9035034Inferred only
MCAM participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
MCAM participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MCAM participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
MCAM participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
MCAM regulates positive regulation of cell migrationBiological processgene ontology P43121|GO:0030335Inferred only

Other names

7 names

Resolves to: MCAM

Also called: CD antigen CD146Cell surface glycoprotein P1H12Melanoma cell adhesion moleculeMelanoma-associated antigen A32Melanoma-associated antigen MUC18MUC18S-endo 1 endothelial-associated antigen

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