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Proteins/UNIPROT:Q7Z6B7

SRGAP1

Protein·UNIPROT:Q7Z6B7

Open in the graph

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42..

Function from UniProtKB (Q7Z6B7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

congenital anomaly of kidney and urinary tract has a germline basis in SRGAP1DiseaseGenCC HGNC:17382|MONDO:0019719Inferred only

Statements

28 statements

28 statements · 3 reference databases · Subject: SRGAP1 · Sources: gene ontology, Hetionet, Reactome

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SRGAP1 covaries with ACTG1ProteinHetionet hetionet:covaries:57522-71Inferred only
SRGAP1 covaries with FAM32AProteinHetionet hetionet:covaries:26017-57522Inferred only
SRGAP1 covaries with HAND2ProteinHetionet hetionet:covaries:57522-9464Inferred only
SRGAP1 covaries with NHLRC4ProteinHetionet hetionet:covaries:283948-57522Inferred only
SRGAP1 covaries with ORMDL2ProteinHetionet hetionet:covaries:29095-57522Inferred only
SRGAP1 covaries with RPL32ProteinHetionet hetionet:covaries:57522-6161Inferred only
SRGAP1 covaries with RPS26ProteinHetionet hetionet:covaries:57522-6231Inferred only
SRGAP1 covaries with SLC61A1ProteinHetionet hetionet:covaries:57522-84975Inferred only
SRGAP1 covaries with WNT7BProteinHetionet hetionet:covaries:57522-7477Inferred only
BMPR1B interacts with SRGAP1ProteinHetionet hetionet:interacts:57522-658Inferred only
CDC42 interacts with SRGAP1ProteinHetionet hetionet:interacts:57522-998Inferred only
FASLG interacts with SRGAP1ProteinHetionet hetionet:interacts:356-57522Inferred only

Show the remaining 16

RHOA interacts with SRGAP1ProteinHetionet hetionet:interacts:387-57522Inferred only
YWHAZ interacts with SRGAP1ProteinHetionet hetionet:interacts:57522-7534Inferred only
SRGAP1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SRGAP1 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
SRGAP1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SRGAP1 participates in Inactivation of CDC42 and RAC1PathwayReactome R-HSA-428543Inferred only
SRGAP1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SRGAP1 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
SRGAP1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
SRGAP1 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
SRGAP1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SRGAP1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
SRGAP1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
SRGAP1 participates in Signaling by ROBO receptorsPathwayReactome R-HSA-376176Inferred only
SRGAP1 regulates negative regulation of cell migrationBiological processgene ontology Q7Z6B7|GO:0030336Inferred only
SRGAP1 regulates regulation of synapse assemblyBiological processgene ontology Q7Z6B7|GO:0051963Inferred only

Other names

3 names

Resolves to: SRGAP1

Also called: ARHGAP13KIAA1304Rho GTPase-activating protein 13

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