Proteins/UNIPROT:Q86VW2

ARHGEF25

ProteinUNIPROT:Q86VW2

May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity)..

Function from UniProtKB (Q86VW2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

25 statements

25 statements · 3 reference databases · Subject: ARHGEF25 · Sources: gene ontology, Hetionet, Reactome

Order

ARHGEF25 covaries with AP5B1ProteinHetionet hetionet:covaries:115557-91056Inferred only
ARHGEF25 covaries with ARHGEF19ProteinHetionet hetionet:covaries:115557-128272Inferred only
ARHGEF25 covaries with CHMLProteinHetionet hetionet:covaries:1122-115557Inferred only
HYAL3 covaries with ARHGEF25ProteinHetionet hetionet:covaries:115557-8372Inferred only
ARHGEF25 covaries with NCKAP5LProteinHetionet hetionet:covaries:115557-57701Inferred only
ARHGEF25 covaries with OMGProteinHetionet hetionet:covaries:115557-4974Inferred only
ARHGEF25 covaries with SOCS2ProteinHetionet hetionet:covaries:115557-8835Inferred only
ARHGEF25 covaries with TOR2AProteinHetionet hetionet:covaries:115557-27433Inferred only
CDC42 interacts with ARHGEF25ProteinHetionet hetionet:interacts:115557-998Inferred only
RAC1 interacts with ARHGEF25ProteinHetionet hetionet:interacts:115557-5879Inferred only
RHOA interacts with ARHGEF25ProteinHetionet hetionet:interacts:115557-387Inferred only
SMAD1 interacts with ARHGEF25ProteinHetionet hetionet:interacts:115557-4086Inferred only

Show the remaining 13

ARHGEF25 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARHGEF25 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
ARHGEF25 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ARHGEF25 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARHGEF25 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGEF25 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGEF25 participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
ARHGEF25 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
ARHGEF25 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGEF25 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ARHGEF25 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGEF25 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGEF25 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q86VW2|GO:0051056Inferred only

Other names

5 names

Resolves to: ARHGEF25

Also called: GEFTGuanine nucleotide exchange factor GEFTp63RhoGEFRac/Cdc42/Rho exchange factor GEFTRhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT

← Every protein Find it in the graph →