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Proteins/UNIPROT:P10911
Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Function from UniProtKB (P10911), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
37 statements
37 statements · 3 reference databases · Subject: MCF2 · Sources: gene ontology, Hetionet, Reactome
4 names
Resolves to: MCF2