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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q7Z5H3

ARHGAP22

Protein·UNIPROT:Q7Z5H3

Open in the graph

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity)..

Function from UniProtKB (Q7Z5H3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

15 statements

15 statements · 4 reference databases · Subject: ARHGAP22 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FRAT1 covaries with ARHGAP22ProteinHetionet hetionet:covaries:10023-58504Inferred only
MESP2 covaries with ARHGAP22ProteinHetionet hetionet:covaries:145873-58504Inferred only
WDFY4 covaries with ARHGAP22ProteinHetionet hetionet:covaries:57705-58504Inferred only
CACNA1A interacts with ARHGAP22ProteinHetionet hetionet:interacts:58504-773Inferred only
ARHGAP22 participates in 10q11 21q11 23 copy number variation syndromePathwayWikiPathways WP5352Inferred only
ARHGAP22 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARHGAP22 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARHGAP22 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGAP22 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGAP22 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGAP22 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGAP22 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only

Show the remaining 3

ARHGAP22 regulates negative regulation of small GTPase mediated signal transductionBiological processgene ontology Q7Z5H3|GO:0051058Inferred only
ARHGAP22 regulates regulation of postsynapse organizationBiological processgene ontology Q7Z5H3|GO:0099175Inferred only
ARHGAP22 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q7Z5H3|GO:0051056Inferred only

Other names

3 names

Resolves to: ARHGAP22

Also called: Rho GTPase-activating protein 22Rho-type GTPase-activating protein 22RHOGAP2

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