Proteins/UNIPROT:A1L390

PLEKHG3

ProteinUNIPROT:A1L390

Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization..

Function from UniProtKB (A1L390), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 3 reference databases · Subject: PLEKHG3 · Sources: gene ontology, Hetionet, Reactome

Order

OR5T3 covaries with PLEKHG3ProteinHetionet hetionet:covaries:26030-390154Inferred only
UBC interacts with PLEKHG3ProteinHetionet hetionet:interacts:26030-7316Inferred only
PLEKHG3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
PLEKHG3 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
PLEKHG3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
PLEKHG3 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
PLEKHG3 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
PLEKHG3 participates in RHOQ GTPase cyclePathwayReactome R-HSA-9013406Inferred only
PLEKHG3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PLEKHG3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
PLEKHG3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
PLEKHG3 regulates regulation of cell migrationBiological processgene ontology A1L390|GO:0030334Inferred only

Show the remaining 3

PLEKHG3 regulates regulation of establishment of cell polarityBiological processgene ontology A1L390|GO:2000114Inferred only
PLEKHG3 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology A1L390|GO:0051056Inferred only
PLEKHG3 increases the expression of CHMP6ProteinHetionet hetionet:regulates:26030-79643Inferred only

Other names

3 names

Resolves to: PLEKHG3

Also called: KIAA0599PH domain-containing family G member 3Pleckstrin homology domain-containing family G member 3

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