Compound

(25R)-cholest-5-ene-3beta,26-diol

A 26-hydroxycholesterol in which the 25-position has R-configuration.

Definition from ChEBI (CHEBI:76591), read 2026-09-23. CC BY 4.0.

CHEBI:76591ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound
Formula: C27H46O2
Mass: 402.663 g/mol
Charge: 0
InChIKey: FYHRJWMENCALJY-YSQMORBQSA-N
SMILES: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@H](C)CCC[C@@H](C)CO
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Chemical structure

(25R)-cholest-5-ene-3beta,26-diol has the functional parent cholesterolCompoundChEBI CHEBI:76591Inferred only

Statements

3 statements

3 statements · 2 reference databases · Subject: (25R)-cholest-5-ene-3beta,26-diol · Sources: Human-GEM, Rhea

Order

CHEBI:1307929 is converted to (25R)-cholest-5-ene-3beta,26-diolCompoundHuman-GEM MAR01762Inferred only
(25R)-cholest-5-ene-3beta,26-diol is metabolised by CYP27A1ProteinRhea RHEA:46400Inferred only
(25R)-cholest-5-ene-3beta,26-diol is metabolised by CYP7B1ProteinHuman-GEM MAR01765Inferred only

Reactions

6 reactions

CHEBI:1307929+proton+NADPH(4-)+dioxygen(25R)-cholest-5-ene-3beta,26-diol+water+NADP(3-)
Catalysed by CYP27A1
Reaction pageLeft to rightBalancedEC 1.14.15.15GO:0005759
Human-GEM MAR01762CC BY 4.0Reference data
(25R)-cholest-5-ene-3beta,26-diol(25R)-cholest-5-ene-3beta,26-diol
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR01764CC BY 4.0Reference data
(25R)-cholest-5-ene-3beta,26-diol+proton+NADPH(4-)+dioxygenMAM01448c+water+NADP(3-)
Catalysed by CYP7B1
Reaction pageLeft to rightBalancedEC 1.14.14.29GO:0005829
Human-GEM MAR01765CC BY 4.0Reference data
(25R)-cholest-5-ene-3beta,26-diol+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:76592+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP7B1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19041CC BY 4.0Reference data
(25R)-cholest-5-ene-3beta,26-diol+2reduced [adrenodoxin]+dioxygen+2hydronCHEBI:86096+2oxidized [adrenodoxin]+2water
Catalysed by CYP27A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46092CC BY 4.0Reference data
2reduced [adrenodoxin]+cholesterol+dioxygen+2hydron(25R)-cholest-5-ene-3beta,26-diol+2oxidized [adrenodoxin]+water
Catalysed by CYP27A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46400CC BY 4.0Reference data

Other names

10 names

Resolves to: (25R)-cholest-5-ene-3beta,26-diol

Also called: (25R)-26-hydroxycholesterol(25R)-cholest-5-ene-3β,26-diol27-hydroxy-cholesterol(25R)27-Hydroxycholesterol5-cholestene-3beta,27-diolcholest-(25R)-5-en-3beta,26-diolCholest-5-ene-3beta,27-diolST 27:1;O2
Systematic name: (3beta,25R)-cholest-5-ene-3,26-diol(3β,25R)-cholest-5-ene-3,26-diol