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CompoundsSubstances with curated findings
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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Compound

(22S)-22-hydroxycholesterol

CHEBI:1301ChEBI

Open in the graph

What it touches on the way

Inferred

Not reported; assembled from reference reactions.

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

CYP11A1ProteinUNIPROT:P05108metabolized byInferred only30 paths30 endpoints

What the reference databases state

Chemical structure

(22S)-22-hydroxycholesterol has the functional parent cholesterolCompoundChEBI CHEBI:1301Inferred only

Statements

3 statements

3 statements · 1 reference database · Subject: (22S)-22-hydroxycholesterol · Sources: Human-GEM

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(22S)-22-hydroxycholesterol is converted to (20R,22R)-20,22-dihydroxycholesterolCompoundHuman-GEM MAR01928Inferred only
CHEBI:1307929 is converted to (22S)-22-hydroxycholesterolCompoundHuman-GEM MAR01927Inferred only
(22S)-22-hydroxycholesterol is metabolised by CYP11A1ProteinHuman-GEM MAR01928Inferred only

Reactions

3 reactions

CHEBI:1307929+proton+NADPH(4-)+dioxygen(22S)-22-hydroxycholesterol+water+NADP(3-)
Catalysed by CYP11A1 or CYP1B1
Reaction pageLeft to rightBalancedEC 1.14.13.-GO:0005759
Human-GEM MAR01927CC BY 4.0Reference data
(22S)-22-hydroxycholesterol+proton+NADPH(4-)+dioxygen(20R,22R)-20,22-dihydroxycholesterol+water+NADP(3-)
Catalysed by CYP11A1
Reaction pageLeft to rightBalancedEC 1.14.15.16GO:0005759
Human-GEM MAR01928CC BY 4.0Reference data
cholesterol+reduced [NADPH--hemoprotein reductase]+dioxygen(22S)-22-hydroxycholesterol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:69839CC BY 4.0Reference data