1-hexadecanoyl-sn-glycero-3-phosphocholine

Three steps

• CHEBI:18019Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol

• L-glutamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosol

• CHEBI:18095Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 2 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7extracellular space, cytosolOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• (5Z)-dodecenoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by LPCAT3, MBOAT7, PLA2G6, PLA2G1B and 17 more

• 3-iodothyronamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 moreOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 8 morecytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 moreOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 8 morecytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 moreOne of 2 routes

• a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + hexadecanoyl-CoA = a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 3 more

• L-thyronineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• thyronamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• 3'-iodothyronamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 moreOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 2 moreOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• 3,3',5'-triiodothyronamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• N-acetylcysteine methyl esterReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
  2. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by PLA2G6, LYPLA1, LYPLA2, PLA2G4B and 14 more

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• a quinolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

  Catalysed by ENPP2, GDPD3, GDPD1, LYPLA2 and 3 more

• hypochlorous acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Peroxidase

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 1 moreextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7 and 2 moreextracellular space, cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. fatty acylamide amidohydrolase

  Catalysed by LPCAT3, MBOAT7, PLA2G6, PLA2G1B and 12 morecytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 6 morecytosolOne of 6 routes

• L-glyceraldehydeReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+)

  Catalysed by PLA2G6, LYPLA1, LYPLA2, PLA2G4B and 16 more

• elaidic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 8 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 3 morecytosol, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, CYP17A1endoplasmic reticulum

• a carboxylateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. an acylcholine + H2O = a carboxylate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by ENPP2, GDPD3, GDPD1, BCHE

• hydrogenselenideReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• formic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, SLC16A4 and 2 moreextracellular space, cytosolOne of 4 routes

• propionic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. transport of acetate and propanoate (cytosol to extracellular)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, SLC16A4 and 3 moreextracellular space, cytosolOne of 2 routes

• butyric acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. transport of acetate and butyrate (cytosol to extracellular)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, SLC16A4 and 3 moreextracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by ENPP2, GDPD3, GDPD1, SLC5A7extracellular space, cytosolOne of 2 routes

• fatty acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. SM pool hydrolysis

  Catalysed by PRDX6, LPCAT3, LPCAT1, SGMS2cytosolOne of 17 routes

• cholesteryl hexadecanoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 3 more

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)
  2. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  3. 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)

  Catalysed by SMPD2, ENPP6, ENPP7, SMPD3 and 3 more

• (S)-lactic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. transport of acetate and L-lactate (cytosol to extracellular)

  Catalysed by LPCAT2, LPCAT1, PLA2G7, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• 25-hydroxycholesterolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)
  2. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  3. 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)

  Catalysed by SMPD2, ENPP6, ENPP7, SMPD3 and 3 more

• N-(acetyl)-sphing-4-enineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by LPCAT2, LPCAT1, PLA2G7, ASAH1

• taurineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ENPP2, GDPD3, GDPD1, CHAT and 1 morecytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by ENPP2, GDPD3, GDPD1, CHDH and 1 more

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by LPCAT3, MBOAT7, PLA2G6, PLA2G1B and 12 morecytosol