Loading the page.
Proteins/UNIPROT:Q6UWV6
Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity. May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity)..
Function from UniProtKB (Q6UWV6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 7 reference databases · Subject: ENPP7 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt
7 reactions
water+a sphingomyelinan N-acylsphing-4-enine+proton+CHEBI:18132
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12cytosol
Human-GEM MAR00795CC BY 4.0Reference data
5 names
Resolves to: ENPP7
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12lysosome
Human-GEM MAR00797CC BY 4.0Reference data
water+MAM02931cproton+CHEBI:18132+sphing-4-enine
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalancedEC 3.1.4.12cytosol
Human-GEM MAR08246CC BY 4.0Reference data
a sphingomyelin+waterphosphocholine+an N-acylsphing-4-enine+hydron
Catalysed by SMPD2 or SMPD1 or ENPP7 or SMPD4 or SMPD3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19253CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycerol+phosphocholine+hydron
Catalysed by SMPD2 or ENPP6 or ENPP7 or SMPD3
Reaction pageLeft to rightBalanced
Rhea RHEA:41119CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-2-acetyl-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP7
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:63380CC BY 4.0Reference data
1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine+water1-O-octadecyl-2-acetyl-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP7
Reaction pageLeft to rightBalanced
Rhea RHEA:63384CC BY 4.0Reference data