leukotriene D4

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

436 compounds within 3 steps: 2 in 1, 74 in 2, 360 in 3

Two steps

glyoxylateReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by DPEP1, DPEP2, AADATOne of 11 routes
glycolithocholic acidReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by DPEP1, DPEP2, BAATcytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by DPEP1, DPEP2, GCATmitochondrial matrix
L-ornithineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. L-Arginine:glycine amidinotransferase
Catalysed by DPEP1, DPEP2, GATMcytosolOne of 5 routes
S(8)-aminomethyldihydrolipoamideReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by DPEP1, DPEP2, GLDC, GCSHmitochondrial matrix
sarcosineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by DPEP1, DPEP2, PIPOXOne of 2 routes
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by DPEP1, DPEP2, SHMT1, SHMT2
an N-acylglycineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by DPEP1, DPEP2, GLYATL3, GLYAT and 1 more
guanidinoacetateReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. L-Arginine:glycine amidinotransferase
Catalysed by DPEP1, DPEP2, GATMcytosolOne of 2 routes
L-methionineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. transport of glycine and methionine (cytosol to extracellular)
Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 5 routes
L-tryptophanReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 5 routes
glutathioneReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by DPEP1, DPEP2, GSS
L-alanineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. transport of alanine and glycine (cytosol to extracellular)
Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 6 routes
leukotriene C4Reach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. leukotriene C4 hydrolysis
Catalysed by DPEP1, DPEP2cytosol
L-asparagineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by DPEP1, DPEP2extracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 7 routes
L-tyrosineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by DPEP1, DPEP2, AADAT
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by DPEP1, DPEP2, AGXT2
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by DPEP1, DPEP2, GLYATL2One of 2 routes
N-benzoylglycineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. Hippurate (Benzoylglycinate) Formation
Catalysed by DPEP1, DPEP2mitochondrial matrixOne of 2 routes
(2S)-2-aminobutanoateReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by DPEP1, DPEP2, AGXT2
glycodeoxycholateReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. Glycodeoxycholate amidohydrolase
Catalysed by DPEP1, DPEP2cytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by DPEP1, DPEP2, GLYATL2
N-eicosanoylglycinateReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by DPEP1, DPEP2, BAAT
N-docosanoylglycineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by DPEP1, DPEP2, BAAT
N-hexacosanoylglycineReach from here →
1. leukotriene D4 + H2O = leukotriene E4 + glycine
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by DPEP1, DPEP2, BAAT

Three steps

beta-carbolineReach from here →
Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by DPEP1, and 2 more