dUTP

Three steps

• Ala-tRNA(Ala)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• thymidineReach from here →
  1. dUTP nucleotidohydrolase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. thymidylate 5'-phosphohydrolase

  Catalysed by DUT, TYMS, ACP3, NT5E and 8 moremitochondrial matrix, cytosolOne of 4 routes

• trans-urocanateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. mitothioredoxin phosphorylation
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosolOne of 5 routes

• fumaric acidReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. sulfotransferase (thioredoxin)
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• triphosphateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• dTDPReach from here →
  1. dUTP nucleotidohydrolase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. DTDP Diphosphohydrolase

  Catalysed by DUT, TYMS, ENTPD3, ENTPD1 and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 11 routes

• dTTPReach from here →
  1. dUTP nucleotidohydrolase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. dTTP + H2O = dTMP + diphosphate + H(+)

  Catalysed by DUT, TYMS, ASMTLmitochondrial matrix, cytosolOne of 4 routes

• CHEBI:18095Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. Transport of Hydroxy-Proline

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• 2-phenylethylamineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• hydrogen cyanideReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. sulfotransferase (thioredoxin)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 4 moremitochondrial matrix, cytosolOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• ophthalmateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. dUTP nucleotidohydrolase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by DUT, TYMS, DHFR, DHFR2mitochondrial matrix, cytosolOne of 5 routes

• S-disulfanyl-L-cysteineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• CHEBI:240943Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 4 moremitochondrial matrix, cytosol

• potassium atomReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 6 moremitochondrial matrix, cytosol, extracellular space

• folic acidReach from here →
  1. dUTP nucleotidohydrolase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by DUT, TYMS, DHFR, DHFR2mitochondrial matrix, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. LTD4 hydrolysis

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 moremitochondrial matrix, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• N-acetyl-L-cysteineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• K(+)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 6 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 31 routes

• glycocholateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 4 moremitochondrial matrix, cytosol

• malonic acidReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. sulfotransferase (thioredoxin)
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• L-lysineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• putrescineReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. mitothioredoxin phosphorylation
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by TXN, RRM1, RRM2, RRM2B and 3 moremitochondrial matrix, cytosol, extracellular space

• N-carbamoyl-L-aspartateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• thiosulfateReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. sulfotransferase (thioredoxin)
  3. 3-mercaptopyruvate:sulfide sulfurtransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 4 moremitochondrial matrix, cytosolOne of 7 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 moremitochondrial matrix, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  2. thioredoxin phosphorylation
  3. De novo synthesis of 2Fe2S

  Catalysed by TXN, RRM1, RRM2, RRM2B and 8 moremitochondrial matrix, cytosol