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Reach

Fe(II)-heme o

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

184 compounds within 3 steps: 4 in 1, 73 in 2, 107 in 3

Does it reach a compound?

Two steps

L-alanineReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by COX15, SCLYOne of 2 routes
biliverdin IXalphaReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. Heme Oxygenase 1
Catalysed by COX10, HMOX1, HMOX2cytosolOne of 2 routes
(2E)-geranyl diphosphateReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate
Catalysed by COX10, GGPS1, FDPS
all-trans-nonaprenyl diphosphateReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. 6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate
Catalysed by COX10, PDSS1, PDSS2
(2E,6E,10E)-geranylgeranyl diphosphateReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. Farnesyltranstransferase
Catalysed by COX10, GGPS1cytosolOne of 2 routes
all-trans-decaprenyl diphosphateReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. decaprenyl diphosphate synthase (farnesyl-PP)
Catalysed by COX10, PDSS1, PDSS2cytosolOne of 2 routes
(2E,6E)-farnesyl triphosphateReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. (2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP
Catalysed by COX10, NME1
a 2,3-saturated acyl-CoAReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by COX15, ACAD10
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by COX15, PTGS1, PTGS2
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by COX15, PTGS1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by COX15, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX15, PTGS2
thio-Mo-molybdopterinReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by COX15, MOCOS
ferroheme c di-L-cysteine(2-) residueReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. Cytochrome c apocytochrome-c-lyase
Catalysed by COX10, HCCSmitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by COX15, PTGS2
(2E,6E)-farnesyl phosphateReach from here →
1. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
2. (2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)
Catalysed by COX10, NUDT18, PLPP6, NUDT15
prostaglandin H1Reach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by COX15, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by COX15, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX15, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX15, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by COX15, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by COX15, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by COX15, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by COX15, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by COX15, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by COX15, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by COX15, PTGS1, PTGS2

Three steps

CHEBI:1146900Reach from here →
Catalysed by COX15, SCLYmitochondrial matrixOne of 2 routes
N(omega)-methyl-L-arginineReach from here →
Catalysed by COX15,

Page 2 of 4

SCLY

, AGXT2

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by COX15, TBXAS1, PTGS2, PTGIS and 1 more

(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

Catalysed by COX15, PTGS2, ALOX5

(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

Catalysed by COX15, PTGS2, ALOX5

2,4-dinitrophenyl-S-glutathioneReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by COX15, DIO1, DIO2, SLCO1A2 and 1 moreextracellular space, cytosolOne of 4 routes

2-glyceryl-prostaglandin D2Reach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2

Catalysed by COX15, PTGS2, HPGDS

2-glyceryl-prostaglandin E2Reach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2

Catalysed by COX15, PTGS2, PTGES

pyruvateReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by COX15, SCLY, AGXT2mitochondrial matrixOne of 14 routes

(S)-2,3-epoxysqualeneReach from here →

heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
Squalene Synthase
squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)

Catalysed by COX10, FDFT1, SQLEendoplasmic reticulum, cytosolOne of 3 routes

CHEBI:15570Reach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
alanine racemase

Catalysed by COX15, SCLYcytosol

L-leucineReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and leucine (cytosol to extracellular)

Catalysed by COX15, SCLY, SLC7A5extracellular space, cytosolOne of 10 routes

15(S)-HPETEReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Glutathione: 15-HPETE oxidoreductase

Catalysed by COX15, TBXAS1, PTGS2, PTGIS and 9 morecytosolOne of 2 routes

CHEBI:15699Reach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and homoserine (cytosol to extracellular)

Catalysed by COX15, SCLY, SLC7A5extracellular space, cytosolOne of 6 routes

betaine aldehydeReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
A + NADH + H(+) = AH2 + NAD(+)
choline + A = betaine aldehyde + AH2

Catalysed by COX15, AIFM1, PYROXD1, CHDH

CHEBI:15971Reach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and histidine (cytosol to extracellular)

Catalysed by COX15, SCLY, SLC7A6extracellular space, cytosolOne of 4 routes

selenophosphateReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)

Catalysed by COX15, SCLY, SEPHS1, SEPHS2

sulfateReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
Steryl-Sulfatase

Catalysed by COX15, DIO1, STSGolgi apparatusOne of 3 routes

L-cystineReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

Catalysed by COX15, SCLY, SLC7A9, SLC3A1extracellular space, cytosol

nitriteReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)

Catalysed by COX15, SUOX, CP

(R)-3-aminoisobutyric acidReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by COX15, SCLY, AGXT2mitochondrial matrix

L-citrullineReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and citrulline (cytosol to extracellular)

Catalysed by COX15, SCLY, SLC7A6extracellular space, cytosolOne of 4 routes

L-valineReach from here →

Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and valine (cytosol to extracellular)

Catalysed by COX15, SCLY, SLC7A5extracellular space, cytosolOne of 9 routes