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Proteins/UNIPROT:Q86YH6
Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. May play a role during cerebellar development (By similarity). May regulate mitochondrial respiratory chain function (By similarity)..
Function from UniProtKB (Q86YH6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
18 statements
18 statements · 5 reference databases · Subject: PDSS2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
(2E,6E)-farnesyl diphosphate+7isopentenyl diphosphateall-trans-decaprenyl diphosphate+7diphosphate(3-)
Reaction pageLeft to rightBalancedEC 2.5.1.91cytosol
Human-GEM MAR06901CC BY 4.0Reference data
7isopentenyl diphosphate+(2E,6E)-farnesyl diphosphateall-trans-decaprenyl diphosphate+7diphosphate(3-)
Catalysed by
7 names
Resolves to: PDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:27802CC BY 4.0Reference data
6isopentenyl diphosphate+(2E,6E)-farnesyl diphosphateall-trans-nonaprenyl diphosphate+6diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:55364CC BY 4.0Reference data