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(2E,6E,10E)-geranylgeranyl diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

16 compounds within 3 steps: 2 in 1, 8 in 2, 6 in 3

Does it reach a compound?

One step

isopentenyl diphosphateReach from here →
1. isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
Catalysed by GGPS1
(2E,6E)-farnesyl diphosphateReach from here →
1. isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
Catalysed by GGPS1

Two steps

squaleneReach from here →
1. isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
2. Squalene Synthase
Catalysed by GGPS1, FDFT1endoplasmic reticulumOne of 3 routes
presqualene diphosphateReach from here →
1. isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
2. farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase
Catalysed by GGPS1, FDFT1cytosolOne of 3 routes
(2E)-geranyl diphosphate

Three steps

(S)-2,3-epoxysqualeneReach from here →
Catalysed by GGPS1, FDFT1, SQLEendoplasmic reticulum, cytosolOne of 3 routes
(2E,6E)-farnesolReach from here →

Reach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
Dimethylallyltranstransferase

Catalysed by GGPS1, FDPSperoxisomeOne of 4 routes

all-trans-nonaprenyl diphosphateReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate

Catalysed by GGPS1, PDSS1, PDSS2One of 2 routes

Fe(II)-heme oReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]

Catalysed by GGPS1, COX10mitochondrial matrixOne of 4 routes

all-trans-decaprenyl diphosphateReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
decaprenyl diphosphate synthase (farnesyl-PP)

Catalysed by GGPS1, PDSS1, PDSS2cytosolOne of 4 routes

(2E,6E)-farnesyl triphosphateReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP

Catalysed by GGPS1, NME1

(2E,6E)-farnesyl phosphateReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)

Catalysed by GGPS1, NUDT18, PLPP6, NUDT15

Catalysed by GGPS1, NUDT18, PLPP6, NUDT15

AH2Reach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

Catalysed by GGPS1, COX10, COX15mitochondrial matrix

heme bReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate

Catalysed by GGPS1, COX10mitochondrial matrix

Fe(II)-heme aReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

Catalysed by GGPS1, COX10, COX15mitochondrial matrix

4-hydroxy-3-(all-trans-decaprenyl)benzoateReach from here →

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate
decaprenyl diphosphate synthase (farnesyl-PP)
solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase

Catalysed by GGPS1, PDSS1, PDSS2, COQ2cytosol, mitochondrial matrixOne of 6 routes