L-tyrosine

Three steps

• hexacosanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 9 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by PAH, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosol

• xanthurenateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by TAT, AADAT, KYAT3

• Mo-molybdopterinReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by PAH, SLC7A5, MOCOSextracellular space, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by AADAT, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by TAT, AADAT, HOGA1

• (R)-noradrenalineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  2. L-dopa + H(+) = dopamine + CO2
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by TH, DDC, DBHcytosolOne of 4 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 4 routes

• CHEBI:742324Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  2. L-dopa + H(+) = dopamine + CO2
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by TH, DDC, COMT, LRTOMTcytosol

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by AADAT, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by AADAT, BAATperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by AADAT, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Suberylcarnitine

  Catalysed by AADAT, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by AADAT, BAATperoxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by AADAT, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by AADAT, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• N-acetyl-L-aspartyl-L-glutamateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC7A13, NAT8L, RIMKLA, RIMKLBinner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartyl-L-glutamyl-L-glutamateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N-acetyl-L-aspartate + 2 L-glutamate + 2 ATP = N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 ADP + 2 phosphate + 2 H(+)

  Catalysed by SLC7A13, NAT8L, RIMKLAinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by AADAT, BAAT, CRAT, CROTperoxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by AADAT, BAAT, ACAA1, HSD17B4 and 2 moreperoxisome

• hexadecanedioyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by AADAT, BAAT, CPT1A, CPT1C and 1 moreperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by AADAT, BAAT, SLC27A2peroxisome, cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by AADAT, BAAT, ACSM4, ACSM1 and 4 moreperoxisome, cytosolOne of 3 routes

• a fatty acyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by AADAT, GLYATL2

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by AADAT, GSS, GPX1, GPX4

• ursodeoxycholateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by AADAT, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• 3-phenyllactateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Phenylalanine Transaminase, Mitochondrial
  3. Formation of Phenyl-Lactate

  Catalysed by PAH, GOT2, TATmitochondrial matrix, cytosol

• prostaglandin G2Reach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by AADAT, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• thio-Mo-molybdopterinReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by PAH, SLC7A5, MOCOSextracellular space, cytosol