N-acetyl-L-aspartyl-L-glutamate

1. N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)

Catalysed by RIMKLA, RIMKLB

1. N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)
2. N-Acetyl-L-aspartate amidohydrolase

Catalysed by RIMKLA, RIMKLB, ASPA, ACY3cytosolOne of 2 routes

1. N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)
2. N-Acetyl-L-aspartate amidohydrolase

Catalysed by RIMKLA, RIMKLB, ASPA, ACY3cytosolOne of 2 routes

1. N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)
2. N-Acetyl-L-aspartate amidohydrolase
3. acetyl-CoA:L-aspartate N-acetyltransferase

Catalysed by RIMKLA, RIMKLB, ASPA, ACY3 and 1 morecytosol, mitochondrial matrix

1. N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)
2. N-Acetyl-L-aspartate amidohydrolase
3. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)