CDP-glycerol

Three steps

• L-cysteineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrix

• CHEBI:17927Reach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 1 morecytosol

• keto-D-fructose 1-phosphateReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. D-fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

  Catalysed by ADPRM, GPD2, ALDOA, ALDOB and 1 morecytosol, mitochondrial matrix

• (5Z)-dodecenoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 7 morecytosolOne of 6 routes

• L-glyceraldehydeReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. sn-glycerol 3-phosphate + H2O = glycerol + phosphate
  3. glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+)

  Catalysed by ADPRM, PGP, AKR1A1, AKR1B1

• elaidic acidReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, peroxisomeOne of 7 routes

• CHEBI:29052Reach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase

  Catalysed by ADPRM, GPD2, TPI1cytosol, mitochondrial matrix

• (S)-dihydroorotateReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by ADPRM, GPD2, DHODH

• beta-D-fructose 1,6-bisphosphateReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

  Catalysed by ADPRM, GPD1, GPD1L, ALDOA and 2 more

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerolReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
  3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• taurineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosolOne of 2 routes

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by ADPRM, GPD2, NQO2

• glycineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 1 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 3 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 7 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Production of Glutaryl Carnitine

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. phytanate-CoA ligase

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 1 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 8 morecytosolOne of 15 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by ADPRM, GPD1, GPD1L, GNPAT

• sn-glycerol 1-phosphateReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. sn-glycerol 3-phosphate + H2O = glycerol + phosphate
  3. sn-glycerol 1-phosphate + H2O = glycerol + phosphate

  Catalysed by ADPRM, PGP

• sphing-4-enineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 5 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 3 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• L-alanineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 1 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by ADPRM, GPD2, GNPATcytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)

  Catalysed by ADPRM, PGS1

• an acyl-CoAReach from here →
  1. CDPglycerol phosphoglycerohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ADPRM, GPAT3, GPAT2, GPAT4 and 5 morecytosol, Golgi apparatusOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by ADPRM, GPD2, PRODH2