eicosanoyl-CoA

Two steps

• L-asparagineReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by BAAT, ACOT6, ACOT1, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by BAAT, ACOT6, ACOT1, NAGScytosol, mitochondrial matrix

• (3Z)-dodecenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by BAAT, ACOT6, ACOT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, GPAT2, LCLAT1 and 9 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 1 morecytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by BAAT, ACOT6, ACOT1, ACSM4 and 5 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 2 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 12 routes

• a cardiolipinReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by HADHAcytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 1 morecytosol

• an all-trans-retinyl esterReach from here →
  1. acyl-CoA pool formation and breakdown
  2. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by DGAT1, PNPLA4, AWAT2, DGAT2cytosol

• CHEBI:63544Reach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2cytosol

• a triacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by DGAT1, MOGAT2, AWAT2, MOGAT3 and 2 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by LCLAT1, LPCAT1, GPAMcytosol

• hexacosanoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 11 routes

• 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA

  Catalysed by ACADM, ACADS, LCLAT1mitochondrial matrix

• docosanoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 10 routes

• 3-oxoeicosasphinganineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

  Catalysed by ACADM, ACADS, SPTLC1, SPTLC2 and 1 moremitochondrial matrix

• 3-oxoeicosanoyl-CoAReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by ACADM, ACADS, ELOVL7, ELOVL1 and 5 moremitochondrial matrix, cytosolOne of 2 routes

• N-(octadecanoyl)-sphinganineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by ACADM, ACADS, CERS1, CERS6 and 4 moremitochondrial matrix

• (2E)-octadecenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 2 morecytosolOne of 9 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 9 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACADM, ACADS, LCLAT1mitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACADM, ACADS, LCLAT1, LPGAT1mitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACADM, ACADS, AGPAT2mitochondrial matrix

• N-octadecanoylsphing-4-enineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by ACADM, ACADS, CERS1, TLCD3B and 2 moremitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACADM, ACADS, LPCAT3mitochondrial matrix

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 5 routes

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by ACADM, ACADS, PHYHmitochondrial matrix

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Eicosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 6 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACADM, ACADS, GPAT3, LCLAT1 and 4 moremitochondrial matrix

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by ACADM, ACADS, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACADM, ACADS, MBOAT1, LPGAT1mitochondrial matrix

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACADM, ACADS, LPGAT1mitochondrial matrix