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Reach

cholesteryl (9Z-octadecenoate)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

372 compounds within 3 steps: 4 in 1, 55 in 2, 313 in 3

Does it reach a compound?

Two steps

cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Catalysed by CEL, CES1, LIPA, LIPE and 3 moreOne of 2 routes
cholesteryl (9Z)-hexadecenoateReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by CEL, CES1, LIPA, LIPE and 2 more
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by CEL, CES1, LIPA, LIPE and 2 moreOne of 2 routes
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. Steryl-ester acylhydrolase
2. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 6 routes
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. Steryl-ester acylhydrolase
2. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 7 routes
4beta-hydroxycholesterolReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 4beta-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, CES1, LIPA, LIPE and 2 more
cholesteryl (5Z,8Z,11Z)-eicosatrienoateReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by CEL, CES1, LIPA, LIPE and 2 more
(6Z,9Z,12Z-octadecatrienoyl)-cholesterolReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by CEL, CES1, LIPA, LIPE and 2 more
cholesteryl (11Z)-octadecenoateReach from here →
1. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
2. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
Catalysed by CEL, CES1, LIPA, LIPE and 2 more

Three steps

(20R,22R)-20,22-dihydroxycholesterolReach from here →
Catalysed by CEL, LIPA, CYP11A1, CYP1B1lysosome, mitochondrial matrixOne of 2 routes
CHEBI:12947Reach from here →

Page 2 of 8

Catalysed by CEL, CES1, LIPA, LIPE and 4 morecytosolOne of 5 routes

(5E)-tetradecenoyl-(R)-carnitineReach from here →

Steryl-ester acylhydrolase
Utilized Transport
carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)

Catalysed by CEL, LIPA, CPT1A, CPT1C and 1 morelysosome, endoplasmic reticulum, cytosolOne of 7 routes

pregnenolone sulfateReach from here →

Steryl-ester acylhydrolase
cytochrome P450 (cholesterol)
3'-phosphoadenylyl-sulfate:pregnenolone sulfotransferase

Catalysed by CEL, LIPA, CYP11A1, SULT2B1lysosome, mitochondrial matrix, cytosolOne of 4 routes

1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerolReach from here →

Steryl-ester acylhydrolase
(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
1-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA

Catalysed by CEL, LIPA, SLC27A2, ACSL3 and 8 morelysosome

N-(9Z-octadecenoyl)glycineReach from here →

Steryl-ester acylhydrolase
(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by CEL, LIPA, SLC27A2, ACSL3 and 8 morelysosome

9-(9Z-octadecenoyloxy)-octadecanoateReach from here →

Steryl-ester acylhydrolase
1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol

Catalysed by CEL, LIPA, DGAT1, PNPLA4 and 2 morelysosome

(24S)-hydroxycholesterol 24-sulfateReach from here →

Steryl-ester acylhydrolase
Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by CEL, LIPA, CYP46A1, SULT2A1lysosome, endoplasmic reticulum

(24S)-hydroxycholesterol 3-sulfateReach from here →

Steryl-ester acylhydrolase
Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by CEL, LIPA, CYP46A1, SULT2B1 and 2 morelysosome, endoplasmic reticulum

a 3-(acyloxy)acyl derivative of bacterial toxinReach from here →

cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Catalysed by CES1, LIPN, NCEH1, LDAH and 1 moreendoplasmic reticulum

1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerolReach from here →

Steryl-ester acylhydrolase
(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA

Catalysed by CEL, LIPA, SLC27A2, ACSL3 and 9 morelysosome

beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enineReach from here →

Steryl-ester acylhydrolase
N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside

Catalysed by CEL, LIPA, ASAH1, ACER2 and 5 morelysosomeOne of 2 routes

an N-acyl-sphinga-4E,14Z-dienineReach from here →

cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Catalysed by CEL, CES1, LIPA, LIPE and 4 more

sn-glycero-3-phosphoethanolamineReach from here →

cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by CEL, CES1, LIPA, LIPE and 3 more

(7Z)-octadecenoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 3 routes

CHEBI:15345Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

cholineReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Acetyl-CoA:choline O-acetyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, nucleusOne of 2 routes

CHEBI:15380Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 2 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Production of Tiglylcarnitine

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 2 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

isobutyryl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, mitochondrial matrix

isovaleryl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
glycine N-acyltransferase (isovalerylglycine)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Arachidonate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 11 routes

CHEBI:15519Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
propanoyl-CoA C-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Palmitate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Phenylacetate:CoA ligase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulum, cytosolOne of 3 routes

propionyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Propanoate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 45 routes

L-leucineReach from here →

Steryl-ester acylhydrolase
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by CEL, LIPA, PM20D1lysosome

1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →

Steryl-ester acylhydrolase
(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by CEL, LIPA, SLC27A2, ACSL3 and 7 morelysosome

CHEBI:15650Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 32 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

S-(9Z-octadecenoyl)-4'-phosphopantetheineReach from here →

Steryl-ester acylhydrolase
(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by CEL, LIPA, SLC27A2, ACSL3 and 7 morelysosome

betaine aldehydeReach from here →

cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
choline + A = betaine aldehyde + AH2

Catalysed by CEL, CES1, LIPA, LIPE and 3 more

CHEBI:15727Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, cytosol

CHEBI:15746Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
diamine N-acetyltransferase (N1-acetylspermine)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 2 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

hexadecanoic acidReach from here →

Steryl-ester acylhydrolase
Acyl-CoA:cholesterol O-acyltransferase
Steryl-ester acylhydrolase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 17 routes

1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →

Steryl-ester acylhydrolase
Phosphatidylcholine:sterol O-acyltransferase
Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

Catalysed by CEL, LIPA, LCAT, LPCAT4 and 3 morelysosome, cytosol

sulfateReach from here →

Steryl-ester acylhydrolase
3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase
Cholesterol-sulfate sulfohydrolase

Catalysed by CEL, LIPA, SULT2B1, SULT1A3 and 1 morelysosome, cytosolOne of 4 routes

11-cis-retinolReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Palmitoyl-CoA:retinol O-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 5 morelysosome, endoplasmic reticulum, cytosol

oxaloacetateReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
ATP citrate lyase (citrate)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

1-phosphatidyl-1D-myo-inositolReach from here →

cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase

Catalysed by CEL, CES1, LIPA, LIPE and 15 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes