chlorine(.)

Three steps

• L-threonylcarbamoyladenylateReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by SLC6A14, SLC1A5, YRDCextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 9 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisomeOne of 3 routes

• (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLC6A14, ALOX12Bextracellular space, cytosol, endoplasmic reticulum

• (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. Arachidonate:oxygen 8-oxidoreductase

  Catalysed by SLC6A14, ALOX12extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. fatty acid amide hydrolase (arachidonate)

  Catalysed by SLC6A14, FAAHextracellular space, cytosol, endoplasmic reticulum

• dodecanedioyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisomeOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Production of Suberylcarnitine

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisomeOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• 2-iminobutanoateReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by SLC6A14, SDS, SDSL, RIDAextracellular space, cytosol

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisome

• (13Z)-eicosenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• 2-aminoprop-2-enoateReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by SLC6A14, SLC1A5, SRRextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 5 routes

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC6A14, CYP2C9extracellular space, cytosol, endoplasmic reticulum

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC6A14, CYP1A1, CYP1A2, CYP2C9 and 2 moreextracellular space, cytosol, endoplasmic reticulum

• beta-citrylglutamateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)

  Catalysed by SLC26A6, SLC25A1, RIMKLBextracellular space, cytosol, mitochondrial matrix

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC6A6, BAAT, CRAT, CROTextracellular space, cytosol, peroxisomeOne of 4 routes

• tetradecanedioyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by SLC6A6, BAAT, ACAA1, HSD17B4 and 2 moreextracellular space, cytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• pristanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by SLC6A6, BAAT, SLC27A2extracellular space, cytosol, peroxisomeOne of 2 routes

• undecanoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by SLC6A6, BAAT, ACSM4, ACSM1 and 4 moreextracellular space, cytosol, peroxisomeOne of 3 routes

• a fatty acyl-CoAReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS1, PTGS2extracellular space, cytosolOne of 2 routes

• (9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS1, PTGS2extracellular space, cytosol

• N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate

  Catalysed by SLC6A14, ASAH1, ACER2, ACER1 and 2 moreextracellular space, cytosol, endoplasmic reticulum

• 18-hydroxy-(9Z)-octadecenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC6A14, CYP4A11, CYP4F11extracellular space, cytosol, endoplasmic reticulum

• ursodeoxycholateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)

  Catalysed by SLC6A14, ABHD12extracellular space, cytosol, endoplasmic reticulum

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosolOne of 3 routes

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosolOne of 3 routes

• 3-phenyllactateReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. Phenylalanine Transaminase, Mitochondrial
  3. Formation of Phenyl-Lactate

  Catalysed by SLC6A14, GOT2, TATextracellular space, cytosol, mitochondrial matrix