iron(2+)

Three steps

• hydrogen sulfideReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• acetateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 7 moremitochondrial matrix, extracellular space, cytosol

• formic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• anthranilic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. L-Kynurenine hydrolase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, cytosol

• propionic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 10 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• butyric acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 10 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and chloride (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, cytosolOne of 2 routes

• L-lysineReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and leucine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-lysineReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and arginine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. De novo synthesis of 2Fe2S
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• 3-oxopropanoateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrixOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 7 moremitochondrial matrix

• 3-methyl-2-oxovaleric acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. De novo synthesis of 2Fe2S
  2. transport of alanine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 7 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix

• glycochenodeoxycholic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, peroxisomeOne of 3 routes

• 3-hydroxyanthranilateReach from here →
  1. De novo synthesis of 2Fe2S
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

• glyoxylateReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 11 routes

• glycolithocholic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix

• (R)-lactic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrixOne of 5 routes

• 25-hydroxycholesterolReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• 2-iminopropanoateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. pyruvate kinase (dTDP)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, cytosol

• 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
  1. Ferrochelatase, Mitochondrial
  2. Heme Oxygenase 1
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

  Catalysed by FECH, HMOX1, HMOX2, ADI1mitochondrial matrix, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. De novo synthesis of 2Fe2S
  2. L-Alanine:glyoxylate aminotransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 7 moremitochondrial matrix

• taurineReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, cytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix

• globinReach from here →
  1. Ferrochelatase, Mitochondrial
  2. globin to hemoglobin conversion
  3. heme oxygenase (biliverdin-producing) (hemoglobin)

  Catalysed by FECH, HMOX1, HMOX2mitochondrial matrix, cytosol

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. De novo synthesis of 2Fe2S
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix

• a 3-acylpyruvateReach from here →
  1. De novo synthesis of 2Fe2S
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix

• (R)-methylmalonyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 11 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 9 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 11 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Production of Glutaryl Carnitine

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. De novo synthesis of 2Fe2S
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 11 moremitochondrial matrix, cytosolOne of 12 routes