L-arginine

Three steps

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by SLC7A6, AADAT, HOGA1extracellular space, cytosolOne of 2 routes

• (R)-noradrenalineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by SLC7A6, GSS, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• CHEBI:730073Reach from here →
  1. L-Arginine amidinohydrolase
  2. Peroxidase
  3. Peroxidase

  Catalysed by ARG1, MPOcytosol, nucleusOne of 3 routes

• L-threonylcarbamoyladenylateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by SLC7A6, SLC7A10, YRDCextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 4-acetamidobutanalReach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by SLC3A2, SLC7A7, SAT1, SAT2 and 5 moreextracellular space, cytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by SLC3A2, SLC7A5, SLC7A6, CPT1A and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Activation of dodecanedioic acid

  Catalysed by SLC3A2, SLC7A5, SLC7A6extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• decanedioyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Production of Sebacoylcarnitine

  Catalysed by SLC3A2, SLC7A5, SLC7A6, CPT1A and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• octanedioyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Production of Suberylcarnitine

  Catalysed by SLC3A2, SLC7A5, SLC7A6, CPT1A and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by SLC3A2, SLC7A5, SLC7A6extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 2-iminobutanoateReach from here →
  1. transport of arginine and threonine (cytosol to extracellular)
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by SLC7A6, SDS, SDSL, RIDAextracellular space, cytosol

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by SLC3A2, SLC7A5, SLC7A6, CPT1A and 2 moreextracellular space, cytosol, mitochondrial matrix

• (13Z)-eicosenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 2-aminoprop-2-enoateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by SLC7A6, SLC7A10, SRRextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SLC7A6, GSS, SLCO2A1extracellular space, cytosolOne of 2 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC3A2, SLC7A5, SLC7A6, CRAT and 1 moreextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by SLC3A2, SLC7A5, SLC7A6, ACAA1 and 3 moreextracellular space, cytosol, mitochondrial matrix, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. Production of Hexadecanedioylcarnitine

  Catalysed by SLC3A2, SLC7A5, SLC7A6, CPT1A and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• O-dodecanoyl-R-carnitineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)

  Catalysed by SLC6A14, CPT1A, CPT1C, CPT1Bextracellular space, cytosolOne of 7 routes

• pristanoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. fatty-acid-CoA ligase

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• undecanoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, ACSM4 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• a fatty acyl-CoAReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC7A6, GSS, GPX1, GPX4extracellular space, cytosolOne of 2 routes

• (9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by SLC7A6, MOCOS, PTGS1, PTGS2extracellular space, cytosol

• ursodeoxycholateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by SLC7A6, GSS, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by SLC7A6, MOCOS, PTGS2extracellular space, cytosol

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by SLC7A6, MOCOS, PTGS2extracellular space, cytosol

• 3-phenyllactateReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Formation of Phenyl-Lactate

  Catalysed by SLC7A6, GOT2, TATextracellular space, cytosol, mitochondrial matrix

• prostaglandin G2Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLC7A6, GSS, SLCO2A1extracellular space, cytosolOne of 2 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC7A6, GSS, GPX1, GPX2 and 1 moreextracellular space, cytosol

• (5Z)-tetradecenoyl-CoAReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC27A2 and 7 moreextracellular space, cytosol, mitochondrial matrixOne of 8 routes