Pathway
Toll Like Receptor 3 (TLR3) Cascade
Toll-like receptor 3 (TLR3) as was shown for mammals is expressed in various tissues and cells, including myeloid dendritic cells, macrophages, respiratory and intestinal epithelium, neurons and microglial cells to induce antiviral and inflammatory responses of the innate immunity in combating viral infections.
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TLR3 recognizes dsRNA in the endosome and that triggers the receptor dimerization. TLR3 recruits the adaptor TRIF (TICAM1), leading to the activation of NF-kappa-B and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.
REACT:R-HSA-168164Reactome
What the reference databases state
Statements
103 statements
103 statements · 1 reference database · Subject: Toll Like Receptor 3 (TLR3) Cascade · Sources: Reactome
- AGER participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- ALPK1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- APP participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- ATF1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- ATF2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- BIRC2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- BIRC3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- BTRC participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- CASP8 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- CHUK participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- CUL1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- DUSP3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
Show the remaining 91
- DUSP4 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- DUSP6 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- DUSP7 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- ELK1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- FADD participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- FBXW11 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- FOS participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- HMGB1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IKBIP participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IKBKB participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IKBKE participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IKBKG participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IRAK1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IRAK2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IRF3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- IRF7 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- JUN participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- LRRC14 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP2K1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP2K3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP2K4 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP2K6 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP2K7 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP3K7 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAP3K8 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK10 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK11 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK14 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK7 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK8 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPK9 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPKAPK2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MAPKAPK3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MEF2A participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- MEF2C participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- N4BP1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NFKB1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NFKB2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NFKBIA participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NFKBIB participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NKIRAS1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NKIRAS2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NLRC5 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NLRX1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NOD1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- NOD2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- OPTN participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- PPP2CA participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- PPP2CB participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- PPP2R1A participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- PPP2R1B participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- PPP2R5D participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RELA participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RIPK1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RIPK2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RIPK3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RPS27A participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RPS6KA1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RPS6KA2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RPS6KA3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- RPS6KA5 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- S100A12 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- S100B participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- SAA1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- SKP1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TAB1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TAB2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TAB3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TANK participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TBK1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TICAM1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TIFA participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TLR3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TNIP2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TP53 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TRAF2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TRAF3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- TRAF6 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBA52 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBB participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBC participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBE2D1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBE2D2 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBE2D3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBE2N participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- UBE2V1 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- USP14 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- USP18 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only
- VRK3 participates in Toll Like Receptor 3 (TLR3) CascadeProteinReactome R-HSA-168164Inferred only