Pathway
Activation of NF-kappaB in B cells
DAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins. Phosphorylated CARMA1 recruits BCL10 and MALT1 to form the CBM complex which, in turn, recruits the kinase TAK1 and the IKK complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). TAK1 phosphorylates the IKK-beta subunit, activating it. The IKK complex then phosphorylates IkB complexed with NF-kappaB dimers in the cytosol, resulting in the degradation of IkB. NF-kappaB dimers are thereby released and are translocated to the nucleus where they activate transcription.
REACT:R-HSA-1169091Reactome
What the reference databases state
Statements
54 statements
54 statements · 1 reference database · Subject: Activation of NF-kappaB in B cells · Sources: Reactome
- ADRM1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- BCL10 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- BTRC participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- CARD11 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- CHUK participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- CUL1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- FBXW11 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- IKBKB participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- IKBKG participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- MALT1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- MAP3K7 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- NFKB1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
Show the remaining 42
- NFKBIA participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- NFKBIB participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- NFKBIE participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PRKCB participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA2 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA3 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA4 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA5 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA6 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMA7 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB2 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB3 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB4 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB5 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB6 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMB7 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMC1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMC2 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMC3 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMC4 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMC5 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMC6 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD11 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD12 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD13 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD14 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD2 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD3 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD6 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD7 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- PSMD8 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- REL participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- RELA participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- RPS27A participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- SEM1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- SKP1 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- UBA52 participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- UBB participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only
- UBC participates in Activation of NF-kappaB in B cellsProteinReactome R-HSA-1169091Inferred only