Pathway
TAK1-dependent IKK and NF-kappa-B activation
NF-kappa-B is sequestered in the cytoplasm in a complex with inhibitor of NF-kappa-B (IkB). Almost all NF-kappa-B activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappa-B from the complex. This allows translocation of NF-kappa-B to the nucleus where it regulates gene expression.
REACT:R-HSA-445989Reactome
What the reference databases state
Statements
44 statements
44 statements · 1 reference database · Subject: TAK1-dependent IKK and NF-kappa-B activation · Sources: Reactome
- AGER participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- ALPK1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- APP participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- CASP8 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- CHUK participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- HMGB1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- IKBIP participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- IKBKB participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- IKBKG participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- IRAK1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- IRAK2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- LRRC14 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
Show the remaining 32
- MAP3K7 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- N4BP1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NFKB1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NFKB2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NFKBIA participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NFKBIB participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NKIRAS1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NKIRAS2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NLRC5 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NLRX1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NOD1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- NOD2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- RELA participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- RIPK2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- RPS27A participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- S100A12 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- S100B participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- SAA1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TAB1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TAB2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TAB3 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TIFA participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TP53 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TRAF2 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- TRAF6 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- UBA52 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- UBB participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- UBC participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- UBE2N participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- UBE2V1 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- USP14 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only
- USP18 participates in TAK1-dependent IKK and NF-kappa-B activationProteinReactome R-HSA-445989Inferred only