Pathway
RIP-mediated NFkB activation via ZBP1
Overexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implicated in ZBP1-induced NFkB activation (Rebsamen M et al 2009; Kaiser WJ et al 2008).
REACT:R-HSA-1810476Reactome
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: RIP-mediated NFkB activation via ZBP1 · Sources: Reactome
- CHUK participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- DHX9 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- IKBKB participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- IKBKG participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- MYD88 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- NFKB1 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- NFKB2 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- NFKBIA participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- NFKBIB participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- NKIRAS1 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- NKIRAS2 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- RELA participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
Show the remaining 5
- RIPK1 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- RIPK3 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- TICAM1 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- TLR3 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only
- ZBP1 participates in RIP-mediated NFkB activation via ZBP1ProteinReactome R-HSA-1810476Inferred only