Pathway
MyD88 dependent cascade initiated on endosome
Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.
REACT:R-HSA-975155Reactome
What the reference databases state
Statements
101 statements
101 statements · 1 reference database · Subject: MyD88 dependent cascade initiated on endosome · Sources: Reactome
- AGER participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- ALPK1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- APP participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- ATF1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- ATF2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- BTRC participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- CASP8 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- CD14 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- CHUK participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- CUL1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- DUSP3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- DUSP4 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
Show the remaining 89
- DUSP6 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- DUSP7 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- ECSIT participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- ELK1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- FBXW11 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- FOS participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- HMGB1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IKBIP participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IKBKB participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IKBKG participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IRAK1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IRAK2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IRAK4 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- IRF7 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- JUN participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- LRRC14 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- LY96 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP2K1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP2K3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP2K4 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP2K6 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP2K7 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP3K1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP3K7 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAP3K8 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK10 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK11 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK14 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK7 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK8 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPK9 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPKAPK2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MAPKAPK3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MEF2A participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MEF2C participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- MYD88 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- N4BP1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NFKB1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NFKB2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NFKBIA participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NFKBIB participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NKIRAS1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NKIRAS2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NLRC5 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NLRX1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NOD1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- NOD2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PELI1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PELI2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PELI3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PPP2CA participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PPP2CB participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PPP2R1A participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PPP2R1B participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- PPP2R5D participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RELA participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RIPK2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RPS27A participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RPS6KA1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RPS6KA2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RPS6KA3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- RPS6KA5 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- S100A12 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- S100B participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- SAA1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- SKP1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TAB1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TAB2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TAB3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TICAM1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TICAM2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TIFA participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TLR4 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TLR7 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TLR9 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TNIP2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TP53 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TRAF2 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- TRAF6 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- UBA52 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- UBB participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- UBC participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- UBE2N participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- UBE2V1 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- USP14 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- USP18 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only
- VRK3 participates in MyD88 dependent cascade initiated on endosomeProteinReactome R-HSA-975155Inferred only