Pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
REACT:R-HSA-975138Reactome
What the reference databases state
Statements
100 statements
100 statements · 1 reference database · Subject: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation · Sources: Reactome
- AGER participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- ALPK1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- APP participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- ATF1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- ATF2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- BTRC participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- CASP8 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- CD14 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- CHUK participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- CUL1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- DUSP3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- DUSP4 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
Show the remaining 88
- DUSP6 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- DUSP7 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- ECSIT participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- ELK1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- FBXW11 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- FOS participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- HMGB1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- IKBIP participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- IKBKB participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- IKBKG participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- IRAK1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- IRAK2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- IRAK4 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- JUN participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- LRRC14 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- LY96 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP2K1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP2K3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP2K4 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP2K6 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP2K7 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP3K1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP3K7 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAP3K8 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK10 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK11 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK14 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK7 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK8 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPK9 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPKAPK2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MAPKAPK3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MEF2A participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MEF2C participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- MYD88 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- N4BP1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NFKB1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NFKB2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NFKBIA participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NFKBIB participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NKIRAS1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NKIRAS2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NLRC5 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NLRX1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NOD1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- NOD2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PELI1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PELI2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PELI3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PPP2CA participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PPP2CB participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PPP2R1A participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PPP2R1B participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- PPP2R5D participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RELA participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RIPK2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RPS27A participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RPS6KA1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RPS6KA2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RPS6KA3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- RPS6KA5 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- S100A12 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- S100B participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- SAA1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- SKP1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TAB1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TAB2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TAB3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TICAM1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TICAM2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TIFA participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TLR4 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TLR7 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TLR9 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TNIP2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TP53 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TRAF2 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- TRAF6 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- UBA52 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- UBB participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- UBC participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- UBE2N participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- UBE2V1 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- USP14 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- USP18 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only
- VRK3 participates in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationProteinReactome R-HSA-975138Inferred only