Proteins/UNIPROT:P02549

SPTA1

ProteinUNIPROT:P02549

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Function from UniProtKB (P02549), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

elliptocytosis 2 has a germline basis in SPTA1DiseaseGenCC HGNC:11272|MONDO:0007533Inferred only
hereditary elliptocytosis has a germline basis in SPTA1DiseaseGenCC HGNC:11272|MONDO:0017319Inferred only
hereditary spherocytosis has a germline basis in SPTA1DiseaseGenCC HGNC:11272|MONDO:0019350Inferred only
hereditary spherocytosis type 3 has a germline basis in SPTA1DiseaseGenCC HGNC:11272|MONDO:0010053Inferred only
pyropoikilocytosis, hereditary has a germline basis in SPTA1DiseaseGenCC HGNC:11272|MONDO:0009948Inferred only

Statements

41 statements

41 statements · 3 reference databases · Subject: SPTA1 · Sources: gene ontology, Hetionet, Reactome

Order

ACY3 covaries with SPTA1ProteinHetionet hetionet:covaries:6708-91703Inferred only
C1orf53 covaries with SPTA1ProteinHetionet hetionet:covaries:388722-6708Inferred only
C2CD4B covaries with SPTA1ProteinHetionet hetionet:covaries:388125-6708Inferred only
EPB42 covaries with SPTA1ProteinHetionet hetionet:covaries:2038-6708Inferred only
MS4A4A covaries with SPTA1ProteinHetionet hetionet:covaries:51338-6708Inferred only
RHAG covaries with SPTA1ProteinHetionet hetionet:covaries:6005-6708Inferred only
SLC4A1 covaries with SPTA1ProteinHetionet hetionet:covaries:6521-6708Inferred only
SPTB covaries with SPTA1ProteinHetionet hetionet:covaries:6708-6710Inferred only
SPTA1 interacts with ABI1ProteinHetionet hetionet:interacts:10006-6708Inferred only
ACTA1 interacts with SPTA1ProteinHetionet hetionet:interacts:58-6708Inferred only
ADD1 interacts with SPTA1ProteinHetionet hetionet:interacts:118-6708Inferred only
SPTA1 interacts with ENAHProteinHetionet hetionet:interacts:55740-6708Inferred only

Show the remaining 29

SPTA1 interacts with EVLProteinHetionet hetionet:interacts:51466-6708Inferred only
FANCC interacts with SPTA1ProteinHetionet hetionet:interacts:2176-6708Inferred only
FASLG interacts with SPTA1ProteinHetionet hetionet:interacts:356-6708Inferred only
PLEC interacts with SPTA1ProteinHetionet hetionet:interacts:5339-6708Inferred only
SLC9A2 interacts with SPTA1ProteinHetionet hetionet:interacts:6549-6708Inferred only
SPTA1 interacts with SPTBProteinHetionet hetionet:interacts:6708-6710Inferred only
SPTA1 interacts with SPTBN1ProteinHetionet hetionet:interacts:6708-6711Inferred only
SPTA1 interacts with SPTBN2ProteinHetionet hetionet:interacts:6708-6712Inferred only
SPTA1 interacts with UBCProteinHetionet hetionet:interacts:6708-7316Inferred only
SPTA1 interacts with VASPProteinHetionet hetionet:interacts:6708-7408Inferred only
SPTA1 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
SPTA1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SPTA1 participates in COPI-mediated anterograde transportPathwayReactome R-HSA-6807878Inferred only
SPTA1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SPTA1 participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
SPTA1 participates in Interaction between L1 and AnkyrinsPathwayReactome R-HSA-445095Inferred only
SPTA1 participates in L1CAM interactionsPathwayReactome R-HSA-373760Inferred only
SPTA1 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
SPTA1 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
SPTA1 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
SPTA1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SPTA1 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
SPTA1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SPTA1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SPTA1 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
SPTA1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SPTA1 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
SPTA1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
SPTA1 regulates regulation of cell shapeBiological processgene ontology P02549|GO:0008360Inferred only

Other names

3 names

Resolves to: SPTA1

Also called: Erythroid alpha-spectrinSpectrin alpha chain, erythrocytic 1SPTA

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