Proteins/UNIPROT:Q5TCZ1

SH3PXD2A

ProteinUNIPROT:Q5TCZ1

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide..

Function from UniProtKB (Q5TCZ1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 2 reference databases · Subject: SH3PXD2A · Sources: Hetionet, Reactome

Order

CD68 covaries with SH3PXD2AProteinHetionet hetionet:covaries:9644-968Inferred only
IL17REL covaries with SH3PXD2AProteinHetionet hetionet:covaries:400935-9644Inferred only
KHNYN covaries with SH3PXD2AProteinHetionet hetionet:covaries:23351-9644Inferred only
MS4A7 covaries with SH3PXD2AProteinHetionet hetionet:covaries:58475-9644Inferred only
ROS1 covaries with SH3PXD2AProteinHetionet hetionet:covaries:6098-9644Inferred only
TATDN2 covaries with SH3PXD2AProteinHetionet hetionet:covaries:9644-9797Inferred only
TRIM68 covaries with SH3PXD2AProteinHetionet hetionet:covaries:55128-9644Inferred only
ADAM15 interacts with SH3PXD2AProteinHetionet hetionet:interacts:8751-9644Inferred only
FASLG interacts with SH3PXD2AProteinHetionet hetionet:interacts:356-9644Inferred only
SH3PXD2A interacts with KHDRBS1ProteinHetionet hetionet:interacts:10657-9644Inferred only
PAK2 interacts with SH3PXD2AProteinHetionet hetionet:interacts:5062-9644Inferred only
SRC interacts with SH3PXD2AProteinHetionet hetionet:interacts:6714-9644Inferred only

Show the remaining 9

SVIL interacts with SH3PXD2AProteinHetionet hetionet:interacts:6840-9644Inferred only
UBC interacts with SH3PXD2AProteinHetionet hetionet:interacts:7316-9644Inferred only
SH3PXD2A participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
SH3PXD2A participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
SH3PXD2A participates in Invadopodia formationPathwayReactome R-HSA-8941237Inferred only
SH3PXD2A participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
SH3PXD2A participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SH3PXD2A participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
SH3PXD2A participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only

Other names

8 names

Resolves to: SH3PXD2A

Also called: Adapter protein TKS5FISHFive SH3 domain-containing proteinKIAA0418SH3 multiple domains protein 1SH3MD1TKS5Tyrosine kinase substrate with five SH3 domains

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