Proteins/UNIPROT:O60504

SORBS3

ProteinUNIPROT:O60504

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Function from UniProtKB (O60504), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

87 statements

87 statements · 3 reference databases · Subject: SORBS3 · Sources: gene ontology, Hetionet, Reactome

Order

ABL1 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-25Inferred only
ADAM15 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-8751Inferred only
SORBS3 interacts with ADAMTSL4ProteinHetionet hetionet:interacts:10174-54507Inferred only
CBL interacts with SORBS3ProteinHetionet hetionet:interacts:10174-867Inferred only
CBLB interacts with SORBS3ProteinHetionet hetionet:interacts:10174-868Inferred only
SORBS3 interacts with CPSF7ProteinHetionet hetionet:interacts:10174-79869Inferred only
SORBS3 interacts with DDX17ProteinHetionet hetionet:interacts:10174-10521Inferred only
DLG5 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-9231Inferred only
SORBS3 interacts with DMRTB1ProteinHetionet hetionet:interacts:10174-63948Inferred only
DVL2 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-1856Inferred only
SORBS3 interacts with EFSProteinHetionet hetionet:interacts:10174-10278Inferred only
FASLG interacts with SORBS3ProteinHetionet hetionet:interacts:10174-356Inferred only

Show the remaining 75

SORBS3 interacts with FLOT1ProteinHetionet hetionet:interacts:10174-10211Inferred only
HNRNPK interacts with SORBS3ProteinHetionet hetionet:interacts:10174-3190Inferred only
INPPL1 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-3636Inferred only
KIAA0408 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-9729Inferred only
SORBS3 interacts with KIAA1217ProteinHetionet hetionet:interacts:10174-56243Inferred only
MAPK1 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-5594Inferred only
MAPK3 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-5595Inferred only
PAK2 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-5062Inferred only
RARG interacts with SORBS3ProteinHetionet hetionet:interacts:10174-5916Inferred only
SORBS3 interacts with RBMXProteinHetionet hetionet:interacts:10174-27316Inferred only
RTKN interacts with SORBS3ProteinHetionet hetionet:interacts:10174-6242Inferred only
SAFB2 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-9667Inferred only
SORBS3 interacts with SOCS7ProteinHetionet hetionet:interacts:10174-30837Inferred only
WASL interacts with SORBS3ProteinHetionet hetionet:interacts:10174-8976Inferred only
ZBED1 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-9189Inferred only
ZBTB25 interacts with SORBS3ProteinHetionet hetionet:interacts:10174-7597Inferred only
SORBS3 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
SORBS3 participates in Smooth Muscle ContractionPathwayReactome R-HSA-445355Inferred only
SORBS3 regulates positive regulation of cytoskeleton organizationBiological processgene ontology O60504|GO:0051495Inferred only
SORBS3 regulates positive regulation of stress fiber assemblyBiological processgene ontology O60504|GO:0051496Inferred only
SORBS3 decreases the expression of AARS1ProteinHetionet hetionet:regulates:10174-16Inferred only
SORBS3 decreases the expression of ANO10ProteinHetionet hetionet:regulates:10174-55129Inferred only
SORBS3 decreases the expression of ATF1ProteinHetionet hetionet:regulates:10174-466Inferred only
AURKAIP1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:54998-10174Inferred only
SORBS3 decreases the expression of C2CD5ProteinHetionet hetionet:regulates:10174-9847Inferred only
SORBS3 decreases the expression of CAB39ProteinHetionet hetionet:regulates:10174-51719Inferred only
SORBS3 decreases the expression of CASC3ProteinHetionet hetionet:regulates:10174-22794Inferred only
CBR1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:873-10174Inferred only
CDK2 increases the expression of SORBS3ProteinHetionet hetionet:regulates:1017-10174Inferred only
SORBS3 decreases the expression of CEBPBProteinHetionet hetionet:regulates:10174-1051Inferred only
CHN1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:1123-10174Inferred only
SORBS3 decreases the expression of CREG1ProteinHetionet hetionet:regulates:10174-8804Inferred only
SORBS3 decreases the expression of CSRP1ProteinHetionet hetionet:regulates:10174-1465Inferred only
CYP51A1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:1595-10174Inferred only
SORBS3 decreases the expression of DERAProteinHetionet hetionet:regulates:10174-51071Inferred only
SORBS3 decreases the expression of DLDProteinHetionet hetionet:regulates:10174-1738Inferred only
E2F5 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:1875-10174Inferred only
SORBS3 decreases the expression of EEF1A2ProteinHetionet hetionet:regulates:10174-1917Inferred only
SORBS3 decreases the expression of EFCAB14ProteinHetionet hetionet:regulates:10174-9813Inferred only
SORBS3 decreases the expression of GLRXProteinHetionet hetionet:regulates:10174-2745Inferred only
GUK1 increases the expression of SORBS3ProteinHetionet hetionet:regulates:2987-10174Inferred only
SORBS3 increases the expression of HERC6ProteinHetionet hetionet:regulates:10174-55008Inferred only
HPRT1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:3251-10174Inferred only
HSP90B1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:7184-10174Inferred only
SORBS3 decreases the expression of IDH1ProteinHetionet hetionet:regulates:10174-3417Inferred only
IMPA2 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:3613-10174Inferred only
KDELR2 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:11014-10174Inferred only
SORBS3 decreases the expression of LBRProteinHetionet hetionet:regulates:10174-3930Inferred only
SORBS3 increases the expression of LIPAProteinHetionet hetionet:regulates:10174-3988Inferred only
SORBS3 increases the expression of MTHFD2ProteinHetionet hetionet:regulates:10174-10797Inferred only
SORBS3 decreases the expression of NCK2ProteinHetionet hetionet:regulates:10174-8440Inferred only
NRAS decreases the expression of SORBS3ProteinHetionet hetionet:regulates:4893-10174Inferred only
SORBS3 increases the expression of NSFProteinHetionet hetionet:regulates:10174-4905Inferred only
PARP10 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:84875-10174Inferred only
PARP4 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:143-10174Inferred only
SORBS3 decreases the expression of PAXBP1ProteinHetionet hetionet:regulates:10174-94104Inferred only
SORBS3 decreases the expression of PPP6R3ProteinHetionet hetionet:regulates:10174-55291Inferred only
PRKACA increases the expression of SORBS3ProteinHetionet hetionet:regulates:5566-10174Inferred only
SORBS3 increases the expression of PSMB2ProteinHetionet hetionet:regulates:10174-5690Inferred only
SORBS3 decreases the expression of PSMD9ProteinHetionet hetionet:regulates:10174-5715Inferred only
PTEN increases the expression of SORBS3ProteinHetionet hetionet:regulates:5728-10174Inferred only
SORBS3 decreases the expression of RNH1ProteinHetionet hetionet:regulates:10174-6050Inferred only
SORBS3 decreases the expression of RPIAProteinHetionet hetionet:regulates:10174-22934Inferred only
SORBS3 decreases the expression of RPN1ProteinHetionet hetionet:regulates:10174-6184Inferred only
SORBS3 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:10174-6192Inferred only
SKIC8 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:80349-10174Inferred only
SORBS3 decreases the expression of SNX6ProteinHetionet hetionet:regulates:10174-58533Inferred only
SORBS3 increases the expression of SRCProteinHetionet hetionet:regulates:10174-6714Inferred only
SUPT4H1 increases the expression of SORBS3ProteinHetionet hetionet:regulates:6827-10174Inferred only
SUPV3L1 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:6832-10174Inferred only
SORBS3 decreases the expression of TMED10ProteinHetionet hetionet:regulates:10174-10972Inferred only
TNFAIP3 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:7128-10174Inferred only
TSPAN8 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:7103-10174Inferred only
UBC increases the expression of SORBS3ProteinHetionet hetionet:regulates:7316-10174Inferred only
ULK3 decreases the expression of SORBS3ProteinHetionet hetionet:regulates:25989-10174Inferred only

Other names

4 names

Resolves to: SORBS3

Also called: SCAM-1SCAM1SH3-containing adapter molecule 1Sorbin and SH3 domain-containing protein 3

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