Proteins/UNIPROT:Q9NSI8

SAMSN1

ProteinUNIPROT:Q9NSI8

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity)..

Function from UniProtKB (Q9NSI8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: SAMSN1 · Sources: gene ontology, Hetionet, WikiPathways

Order

FASLG interacts with SAMSN1ProteinHetionet hetionet:interacts:356-64092Inferred only
HDAC1 interacts with SAMSN1ProteinHetionet hetionet:interacts:3065-64092Inferred only
NEDD4 interacts with SAMSN1ProteinHetionet hetionet:interacts:4734-64092Inferred only
SAP30 interacts with SAMSN1ProteinHetionet hetionet:interacts:64092-8819Inferred only
SFN interacts with SAMSN1ProteinHetionet hetionet:interacts:2810-64092Inferred only
YWHAB interacts with SAMSN1ProteinHetionet hetionet:interacts:64092-7529Inferred only
YWHAE interacts with SAMSN1ProteinHetionet hetionet:interacts:64092-7531Inferred only
YWHAG interacts with SAMSN1ProteinHetionet hetionet:interacts:64092-7532Inferred only
YWHAH interacts with SAMSN1ProteinHetionet hetionet:interacts:64092-7533Inferred only
YWHAQ interacts with SAMSN1ProteinHetionet hetionet:interacts:10971-64092Inferred only
YWHAZ interacts with SAMSN1ProteinHetionet hetionet:interacts:64092-7534Inferred only
SAMSN1 participates in TYROBP causal network in microgliaPathwayWikiPathways WP3945Inferred only

Show the remaining 4

SAMSN1 regulates negative regulation of adaptive immune responseBiological processgene ontology Q9NSI8|GO:0002820Inferred only
SAMSN1 regulates negative regulation of B cell activationBiological processgene ontology Q9NSI8|GO:0050869Inferred only
SAMSN1 regulates negative regulation of peptidyl-tyrosine phosphorylationBiological processgene ontology Q9NSI8|GO:0050732Inferred only
SAMSN1 regulates regulation of intracellular signal transductionBiological processgene ontology Q9NSI8|GO:1902531Inferred only

Other names

5 names

Resolves to: SAMSN1

Also called: HACS1Hematopoietic adaptor containing SH3 and SAM domains 1Nash1SAM domain, SH3 domain and nuclear localization signals protein 1SH3-SAM adaptor protein

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